Postdoc position at Columbia University—Cancer Immunology and Immunotherapy

Location
New York City, New York (US)
Salary
commensurate with experience
Posted
September 04 2018
Position Type
Full Time
Organization Type
Academia
Job Type
Postdoc

Two postdoctoral research positions are available in the laboratory of Charles Drake, MD, PhD at Columbia University. The focus of the Drake laboratory is to investigate mechanisms of resistance of genitourinary cancers (prostate, bladder and kidney) to immunotherapy, with an emphasis on improving clinical responses to immunotherapy and checkpoint blockade.  

One project focuses on regulatory T cells (Treg) in cancer; using RNA-sequencing we’ve identified a number of novel Treg molecules relatively over-expressed on tumor-infiltrating Treg in human samples; this project focuses on exploring the biology of these molecules in physiologically relevant murine models and human tissue samples.  The second project focuses on the myeloid components in the immunosuppressive tumor microenvironment in genitourinary tumors, particularly on the unique biology of myeloid suppressor cells (MDSC).  Both projects have the potential for direct translation to interventional clinical trials, as well as the opportunity for correlative translational studies.

Successful candidates will have a Ph.D. and/or M.D. degree, and a strong background in human and mouse immunology and/or immuno-oncology.  Experience in RNA sequencing and computational analysis of large datasets is a plus.  To apply for these positions, please send your CV with names/contact info for 3 references to Dr. Charles Drake  (cgd2139@cumc.columbia.edu) and Andreina Rodriguez (ar3557@cumc.columbia.edu).

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