Postdoctoral Fellow Position

Location
Boston, Massachusetts (US)
Salary
Follow NIH guidelines + benefits
Posted
September 04 2018
Ref
Postdoctoral Fellow Position - HMS/BWH
Position Type
Full Time
Organization Type
Academia

Harvard Medical School

We are seeking a highly motivated postdoctoral research fellow to study mechanisms of neurodegeneration in Alzheimer's and Parkinson’s diseases in the laboratory of Prof. Jie Shen at Harvard Medical School and Brigham and Women’s Hospital (www.shenlab.net).

We employ mouse and Drosophila genetic approaches to elucidate functions of gene products involved in Alzheimer’s and Parkinson’s disease in relevant neural circuits and identify molecular pathways regulated by the disease genes. We also use cell culture, biochemical, imaging and viral approaches to investigate molecular and cellular mechanisms. Our work is funded by five NIH grant awards including a center grant. Areas of research include:

  1. We apply state of the art genetic approaches to dissect the physiological roles of Presenilins and the amyloid precursor protein (APP), two major gene families linked to familial Alzheimer’s disease, in the developing and adult brain. We also investigate the cellular and molecular mechanisms by which mutations in Presenilins and APP cause dementia and neurodegeneration. Some of our publications include Nature 460:632-6, J Biol Chem 285:22350-9, J Neurosci 32:5085-5096, PNAS 110:15091-6, PNAS 111:8973-8, Neuron 85: 967-81, J Neurosci 34: 15912-22, Neuron 90: 417-422, Genetics 206: 1479-93.
  2. We are the home of the BWH Udall Center of Excellence for Parkinson’s disease (udallcenter.bwh.harvard.edu), one of the 9 NIH funded Udall Centers across the U.S. Our center focuses on the interplay between LRRK2 and alpha-synuclein, and includes the Südhof lab at Stanford and the Yue Lab at Mt. Sinai School of Medicine. Relevant publications include PNAS 106:14622-7, PNAS 107:9879-84, Mol Neurodegen 7:2, and Neuron 96:796-807.

Recent PhDs in neurobiology with strong expertise in slice electrophysiology, stereotaxic injection, imaging, mouse and fly genetics, and molecular biology are encouraged to apply. Candidates should have a strong, current publication record, and be both self-motivated and capable of working collaboratively. Please send CV to Dr. Jie Shen at jshen@bwh.harvard.edu.

Apply for Postdoctoral Fellow Position

Already uploaded your resume? Sign in to apply instantly

Apply

Upload from your computer

Or import from cloud storage

Your Resume must be a .doc, .pdf, .docx, .rtf, and no bigger than 1Mb


Upload from your computer

Or import from cloud storage

Your Supplementary Documents must be a .doc, .pdf, .docx, .txt, .rtf, and no bigger than 1Mb


4000 characters left

Marketing Communication

We'd love to send you information about Jobs and Services from Science Careers by email.

All emails will contain a link in the footer to enable you to unsubscribe at any time.


When you apply for a job we will send your application to the named recruiter, who may contact you. By applying for a job listed on Science Careers you agree to our terms and conditions and privacy policy. You should never be required to provide bank account details. If you are, please email us.

Similar jobs

Similar jobs