Post-doctoral position in RNA biology at NCI's Shalini Oberderoffer's lab

Location
National Institute of Health, Bethesda,Maryland
Salary
Salary is commensurate with experience
Posted
September 02 2018
Position Type
Full Time
Organization Type
Govt.

Post-doctoral position in RNA biology

at NCI's Shalini Oberderoffer's lab

The Center for Cancer Research (CCR), in the National Cancer Institute (NCI) invites applications for a Post-doctoral position in the Laboratory of Receptor Biology and Gene Expression, located in Bethesda, Maryland.  The laboratory is interested in the role of the epigenome and epitranscriptome in mRNA processing and function. We examine the role of DNA methylation in co-transcriptional pre-mRNA splicing, and the influence of mRNA modifications in post-transcriptional mRNA regulation. Projects in the laboratory are highly integrated and utilize a variety of approaches ranging from the biochemical to genome/transcriptome-wide profiling. The position to be filled is to specifically examine the role of mRNA acetylation in promoting mRNA stability and efficient translation. Anticipated methodologies include base-resolution mapping of modified nucleotides, CRISPR/Cas9-guided mutation of responsible enzymes, mass spectrometry to identify associated factors, and the development of in vitro approaches to examine translation.

For more information, see: https://ccr.cancer.gov/Laboratory-of-Receptor-Biology-and-Gene-Expression/shalini-oberdoerffer.          

We are seeking an enthusiastic and highly qualified individual to join an integrated team of bench and computational scientists with common research interests. While candidates with a wide range of expertise will be considered, applicants with a background in bioinformatics/computational biology are especially encouraged to apply. Expertise in the analysis of RNA-sequencing data, particularly from single cell and/or long-read single molecule (nanopore) data, is especially preferred. Applicants must possess a Ph.D. or equivalent and have no more than two years of post-doctoral experience. Successful applicants should have a strong theoretical background in gene regulation and RNA biology.

The Center for Cancer Research (CCR) is the intramural research component of the NCI. CCR’s enabling infrastructure facilitates clinical studies at the NIH Clinical Center, provides extensive opportunities for collaboration, and allows scientists and clinicians to undertake high-risk, high-impact laboratory and clinically based investigations. Investigators are supported by a wide array of intellectual, technological and research resources including, animal facilities and dedicated, high-quality technology cores in areas such as imaging/microscopy, chemistry/purification, mass spectrometry, flow cytometry, genomics/DNA sequencing, transgenics and knockout mice, arrays/molecular profiling, and human genetics/bioinformatics.  For an overview of CCR, please visit http://ccr.cancer.gov/.

Interested individuals should send a curriculum vitae and bibliography, a brief summary of research interests and accomplishments, scientific experience, and the names and addresses of three references to:

Dr. Shalini Oberdoerffer, Investigator

LRBGE, National Cancer Institute

E-mail: shalini.oberdoerffer@nih

 

  DHHS, NIH, and NCI are Equal Employment Opportunity Employers        

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