Bioinformatician in Single Cell Biology and Reprogramming

Employer
Lund University Stem Cell Center
Location
Lund (Kommun), Skåne (SE)
Salary
Attractive salary, benefits and progression are offered.
Posted
August 29 2018
Position Type
Full Time
Organization Type
Academia

Bioinformatician in Single Cell Analysis and Epigenetic Reprogramming

 

Reprogramming and Hematopoiesis lab

Cellular reprogramming can be achieved experimentally in different ways, including

nuclear transfer, cell fusion or expression of transcription factors. We aim to uncover

how hematopoietic stem and effector cell identity is established employing cellular

reprogramming logic. Ultimately our work may allow the generation of patient-specific

hematopoietic cells for regenerative medicine and immunotherapy. To explore these

aims, we use a variety of approaches, including cellular reprogramming through gene

transduction (Pereira et al, Cell Stem Cell, 2013) and single cell gene expression and

epigenetic profiling during embryonic development (Pereira et al, Developmental Cell,

2016).

We are currently generating large amounts of population and single cell data along with

chromatin accessibility and transcription factor occupancy in both mice and humans. We

are looking for a postdoctoral fellow with a strong background in bioinformatics that is

interested in extracting biologic information from large datasets and harnessing on

the full potential of single cell analysis. Our lab is generously funded by the

Wallenberg Centre for Molecular Medicine and the Knut and Alice Wallenberg

Foundation, Cancerfonden and the Crafoord Foundation.

 

Candidate Profile

The candidate should be an enthusiastic and motivated scientist, with a background in

bioinformatics, willing to join a young international research group in a highly dynamic

and multidisciplinary environment (with English as main language). Candidates with a

passion for cell identity, epigenetics and single cell analysis who recently completed their

PhD thesis or currently finishing up are encouraged to apply. The ideal candidate should

have experience in next generation sequencing data analysis, programming and

scripting languages as well as a large array of bioinformatic tools and graphic tools in R.

Experience with building websites for making data available to the community is

preferential. Excellent verbal and written communication skills in English are required.

 

Research at Lund University

Lund University is Scandinavia’s largest institution for education and research and

consistently ranks among the world’s top 100 universities. The Lund Stem Cell Center

hosts 15 research groups in experimental hematology and is one of Europe’s most

prominent in the field of hematopoietic research. This environment has all facilities and

equipment essential for the project including an outstanding animal facility, technical

platforms for flow cytometry and cell sorting, a human ES/iPS core facility, viral vector

technology and single cell genomics facility. This creates a very interactive environment

with weekly seminars and annual retreats for students, postdocs and PIs.

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