A postdoctoral position in breast cancer research at Northwestern University in Chicago

Chicago, Illinois
NIH standard
August 26 2018
Position Type
Full Time
Organization Type

A postdoctoral position is available in a breast cancer research lab (Dai Horiuchi, Principal Investigator) at Northwestern University Feinberg School of Medicine and Robert H. Lurie Comprehensive Cancer Center in Chicago.

The primary focus of the lab is to study the mechanisms of tumor progression in breast cancer, with our focus on the triple-negative breast cancer (TNBC) subtype, and to identify novel targeted treatment strategies. To achieve these goals, we utilize a collection of human breast cancer cell lines, preclinical animal models, primary tumor organoids ex vivo, and high-throughput screening approaches along with state-of-the-art bioinformatics through collaboration with experts in the field. We are determined to help bring basic laboratory findings to clinical testing, and our research involves dynamic interactions with clinical investigators here at Northwestern Medicine and industry partners.

We are interested in identifying a highly motivated new team member in one of the following two research areas: 

(1) Functional studies on the biology and therapeutic targetability of novel molecular factors (cell-fate determining transcription factors and genes thought to control cell metabolism, cellular stresses, among others) that we have found to be correlated with patient clinical outcome significantly. Some of the side projects include preclinical validation of our lab-identified potential targeted therapeutic strategies and their translation to early-stage clinical testing in collaboration with clinical investigators. 

(2) Functional studies focused on understanding the mechanisms by which an immunosuppressive TNBC microenvironment is generated and maintained. We are particularly interested in studying such immunosuppressive mechanisms that are independent of the currently well-studied immune checkpoint regulators. This project requires advanced training in immunology (with emphasis on T cell biology). Solid understanding of the current literature in immuno-oncology would be valuable.

Prior in-depth training in (breast) cancer research involving rodent animal models (e.g., transgenic/syngeneic/PDX) and advanced molecular and cell biological experimental skills as demonstrated by peer-reviewed publications is a must for this position. Additionally, a solid understanding of global gene expression and statistical analysis methods is required. Also essential is an ability to communicate with others effectively and efficiently as this position requires constant communication with our collaborators on and off campus. This position is most suitable for an individual who is capable of functioning in a fast-paced environment semi-independently with minimum guidance.

Overall cancer research at Northwestern is on an exciting, rapid growth phase and provides enormous opportunities for us to positively impact the lives of cancer patients through innovative basic and translational research. Please send an email with a brief introduction of your academic/research background and current career goals, curriculum vitae, and contact info for three references to Dai Horiuchi, Ph.D., Department of Pharmacology, R.H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine at horiuchilab123@gmail.com. Successful candidates will be contacted via email.


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