Senior Biologist, Proteomics
Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.
The Paulovich Lab at Fred Hutch (http://research.fhcrc.org/paulovich/en.html) is an interdisciplinary team whose mission is to develop and implement tools for protein quantification to enable precision medicine. Our group is highly collaborative, participating in national and international consortia in which teams of scientists, statisticians, and clinicians work together to solve clinical or biological problems to impact human health.
This is a terrific leadership opportunity for a highly motivated, interactive, upper level biologist to join our translational proteomics team to help drive translational projects forward towards clinical applications by participating in planning and executing proteomic experiments, and spearheading the analysis and interpretation of proteomic results.
- Generate mass spectrometry (MS)-based proteomics data (training will be provided for the candidate with excellent qualifications but no prior MS experience)
- Analyze proteomic (mass spectrometry) datasets and contribute to interpreting the results to discern clinical or biological insights from proteomics and proteogenomic experiments
- Think independently about new results, connect them to domain knowledge, and formulate novel and testable hypotheses to glean clinical or biological insights; communicate new ideas to the team frequently and effectively (i.e., an interactive thought leader)
- Collaborate effectively with an interdisciplinary team spanning expertise in biology, analytical chemistry, and statistics
- Collaborate with others to develop new methods and tools that support research objectives
- Prepare and deliver presentations (oral, poster, and written reports)
- Prepare and publish scientific manuscripts (in peer-reviewed journals) and reports
- Ph.D. degree and 3+ years experience in Biology, Molecular Genetics, or related discipline (Master’s degree is acceptable for the exceptional candidate)
- Previous hands-on bench experience in analytical chemistry, biochemistry, or molecular biology
- The position includes drafting manuscripts for publication and giving oral presentations on consortium teleconferences as well as national and international meetings; thus a demonstrated track record of peer-reviewed journal publications (including publications as first author), as well as excellent English written and oral communication skills, are required.
- The work is rigorously quantitative, and exquisite attention to detail and the ability to adhere to standard operating protocols (SOP) are critical.
- Fundamental understanding of cancer biology
- Ability to read and critically evaluate scientific literature related to team projects
- Ability to think independently about new results, connect them to domain knowledge, and formulate novel and testable hypotheses to glean clinical or biological insights
- Ability to work as part of an interdisciplinary team
- Ability to function independently with minimal supervision
- Proficiency with MS Office programs (Word, Powerpoint, Excel, and Access)
- Ability to multi-task efficiently in a highly interactive team environment
- Must be comfortable in a milestone-driven environment, with quarterly objectives
- Willingness to learn new techniques
- Passion for translational biology and strong work ethic
- Basic familiarity with mass spectrometry fundamentals and associated data (discovery shotgun MS and targeted LC-MRM-MS) is a plus
- Previous work in cancer biology, DNA damage response, or immunotherapy is a plus
- Previous experience in a CLIA or clinical lab environment is a plus
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