Biology of Lung Repair and Regeneration

Employer
University of California San Francisco
Location
San Francisco, California
Salary
Commensurate with NIH guidelines plus housing supplement for San Francisco
Posted
August 22 2018
Position Type
Full Time
Organization Type
Academia

Biology of Lung Repair and Regeneration

The Chapman laboratory focuses on mechanisms underlying tissue remodeling after major injury to mouse and human lungs.  The scope of projects centered on this theme range from basic studies of distal airway stem/progenitor cells responding to alveolar injury to development of small molecules identified through high throughput screens that selectively target fibroblast collagen production.  See recent publications:  Xi et al, NCB 19:904, 2017; Wei et al JCI, October, 2017.  Planned projects will involve substantial biochemistry and organoid biology in vitro, in vivo functional assays in injury models, time lapse and high resolution microscopy, and genetically modified mice as reporters and tools for lineage tracing.  We benefit from close proximity to UCSF Medical Center where an active transplantation program affords access to normal and diseased human lungs.

We are interested in recruiting a talented postdoctoral scientist motivated to address either of two current projects in the lab :

a)  Develop a signaling “toolkit” that converts the mal-adaptive microenvironment of injured lungs into a receptive environment either for endogenous epithelial cell stem/progenitor expansion or for engraftment and improved function after transplantation of exogenous normal stem/progenitors.  This project will require improved understanding of the key drivers and regulation of distal airway epithelial stem/progenitor cell mobilization, migration, and differentiation after major lung injury. 

b)  Define the mechanisms by which TGFb1 signaling is attenuated in the context of injury and inflammation to promote regeneration and avoid fibrosis.  A current project is defining the biochemical basis for and functional implications of a newly recognized interaction between TGFb1 receptors and a target of TGFb1 signaling, lysyl oxidase-like 2 (LOXL2).   We are interested in defining the role of LOXL2, and potentially other TGFb1 gene targets, in regulating the timing and duration of TGFb1 signaling during tissue repair.   This project explores the untested thesis that one pathway to progressive tissue fibrosis is failure of feedback negative signals to limit TGFb1 signaling.

There is certainly also opportunity for novel research directions that a new scientist in the lab is motivated to initiate and pursue.   We expect the successful candidate to have experience in cell and molecular biology, a genuine interest in repair processes including that of the lung, experience with mouse models, and at least one first author publication.  Strong organizational skills, lab notebook practices, and attention to detail are vital.   Send CV, summary of research experience and training, and the names and contact details of 3 referees to Hal Chapman (hal.chapman@ucsf.edu).

The University of California is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age or protected veteran status.

Chapman Lab, Cardiovascular Research Institute and Department of Medicine, Pulmonary and Critical Care Division, UCSF Parnassus campus.

Apply for Biology of Lung Repair and Regeneration

Already uploaded your resume? Sign in to apply instantly

Apply

Upload from your computer

Or import from cloud storage

Your Resume must be a .doc, .pdf, .docx, .rtf, and no bigger than 1Mb


Upload from your computer

Or import from cloud storage

Your Supplementary Documents must be a .doc, .pdf, .docx, .txt, .rtf, and no bigger than 1Mb


4000 characters left

Marketing Communication

We'd love to send you information about Jobs and Services from Science Careers by email.

All emails will contain a link in the footer to enable you to unsubscribe at any time.


When you apply for a job we will send your application to the named recruiter, who may contact you. By applying for a job listed on Science Careers you agree to our terms and conditions and privacy policy. You should never be required to provide bank account details. If you are, please email us.

Similar jobs

Similar jobs