Postdoctoral Fellowship in Neuroscience and Regenerative Medicine

Employer
bo.chen@mssm.edu (Icahn School of Medicine at Mount Sinai)
Location
New York City, New York (US)
Salary
Pay on NIH scale plus benefits
Posted
August 22 2018
Position Type
Full Time
Organization Type
Academia

We are looking for highly motivated postdocs to join our research in neural degeneration and regeneration in the mammalian retina at Mount Sinai School of Medicine in New York City. Our main research interests focus on the mechanistic and therapeutic studies of neurodegenerative diseases in the retina resulting in vision impairment and blindness. We study signaling pathways and gene expression network in retinal neurons in normal and diseased conditions, with an ultimate aim to save vision.

For neuroprotection, we investigate molecular mechanisms underlying the degeneration of photoreceptors and retinal ganglion cells. An in-depth understanding the signaling pathways that are perturbed in a diseased retina will facilitate the design of therapeutic strategies to protect these retinal neurons through modulation of the affected pathways.

For neural regeneration, we examine the intrinsic signaling pathways and transcription control in Müller glial cells, the primary glial cell type in the retina, in order to reprogram them in vivo to generate adult retinal stem cells that are capable of differentiating to retinal neurons and restore visual function.

Using optic nerve crush to model CNS (central nervous system) injury, we manipulate signaling pathways in retinal ganglion cells to promote axon regeneration.

Our representative publications:

Yao K, Qiu S, Wang YV, Park SJ, Mohns EJ, Mehta B, Liu X, Chang B, Zenisek D, Crair MC, Demb JB, Chen B. Restoration of vision after de novo genesis of rod photoreceptors in mammalian retinas. Nature. 2018 Aug 15.

Yao K, Qiu S, Tian L, Snider WD, Flannery JG, Schaffer DV, Chen B. Wnt Regulates Proliferation and Neurogenic Potential of Müller Glial Cells via a Lin28/let-7 miRNA-Dependent Pathway in Adult Mammalian Retinas. Cell reports 2016 09; 17(1).

Guo X, Snider WD, Chen B. GSK3β regulates AKT-induced central nervous system axon regeneration via an eIF2Bε-dependent, mTORC1-independent pathway. eLife 2016 Mar; 5.

Guo X, Wang SB, Xu H, Ribic A, Mohns EJ, Zhou Y, Zhu X, Biederer T, Crair MC, Chen B. A short N-terminal domain of HDAC4 preserves photoreceptors and restores visual function in retinitis pigmentosa. Nature communications 2015 Aug; 6.

To apply, please send your CV, and a statement of your past work and future interests to Dr. Bo Chen (bo.chen@mssm.edu).

Apply for Postdoctoral Fellowship in Neuroscience and Regenerative Medicine

Already uploaded your resume? Sign in to apply instantly

Apply

Upload from your computer

Or import from cloud storage

Your Resume must be a .doc, .pdf, .docx, .rtf, and no bigger than 1Mb


Upload from your computer

Or import from cloud storage

Your Supplementary Documents must be a .doc, .pdf, .docx, .txt, .rtf, and no bigger than 1Mb


4000 characters left

Marketing Communication

We'd love to send you information about Jobs and Services from Science Careers by email.

All emails will contain a link in the footer to enable you to unsubscribe at any time.


When you apply for a job we will send your application to the named recruiter, who may contact you. By applying for a job listed on Science Careers you agree to our terms and conditions and privacy policy. You should never be required to provide bank account details. If you are, please email us.

Similar jobs

Similar jobs