Postdoctoral Fellowship in Neuroscience and Regenerative Medicine
We are looking for highly motivated postdocs to join our research in neural degeneration and regeneration in the mammalian retina at Mount Sinai School of Medicine in New York City. Our main research interests focus on the mechanistic and therapeutic studies of neurodegenerative diseases in the retina resulting in vision impairment and blindness. We study signaling pathways and gene expression network in retinal neurons in normal and diseased conditions, with an ultimate aim to save vision.
For neuroprotection, we investigate molecular mechanisms underlying the degeneration of photoreceptors and retinal ganglion cells. An in-depth understanding the signaling pathways that are perturbed in a diseased retina will facilitate the design of therapeutic strategies to protect these retinal neurons through modulation of the affected pathways.
For neural regeneration, we examine the intrinsic signaling pathways and transcription control in Müller glial cells, the primary glial cell type in the retina, in order to reprogram them in vivo to generate adult retinal stem cells that are capable of differentiating to retinal neurons and restore visual function.
Using optic nerve crush to model CNS (central nervous system) injury, we manipulate signaling pathways in retinal ganglion cells to promote axon regeneration.
Our representative publications:
Yao K, Qiu S, Wang YV, Park SJ, Mohns EJ, Mehta B, Liu X, Chang B, Zenisek D, Crair MC, Demb JB, Chen B. Restoration of vision after de novo genesis of rod photoreceptors in mammalian retinas. Nature. 2018 Aug 15.
Yao K, Qiu S, Tian L, Snider WD, Flannery JG, Schaffer DV, Chen B. Wnt Regulates Proliferation and Neurogenic Potential of Müller Glial Cells via a Lin28/let-7 miRNA-Dependent Pathway in Adult Mammalian Retinas. Cell reports 2016 09; 17(1).
Guo X, Snider WD, Chen B. GSK3β regulates AKT-induced central nervous system axon regeneration via an eIF2Bε-dependent, mTORC1-independent pathway. eLife 2016 Mar; 5.
Guo X, Wang SB, Xu H, Ribic A, Mohns EJ, Zhou Y, Zhu X, Biederer T, Crair MC, Chen B. A short N-terminal domain of HDAC4 preserves photoreceptors and restores visual function in retinitis pigmentosa. Nature communications 2015 Aug; 6.
To apply, please send your CV, and a statement of your past work and future interests to Dr. Bo Chen (firstname.lastname@example.org).