Postdocs, PhD students in Molecular Infection Medicine, Sweden
Postdocs, PhD students in Molecular Infection Medicine, Umeå University, Sweden
The Laboratory for Molecular Infection Medicine Sweden (MIMS), the Swedish Partner in the Nordic EMBL Partnership for Molecular Medicine, is establishing new research groups and seeks Postdocs and PhD students. We are looking for qualified candidates interested in joining the highly interactive and multidisciplinary and international research environment for molecular infection medicine at Umeå University and the affiliated lab of a MIMS Clinical Research Fellow at Lund University (note different deadlines!)
Several Postdoctoral positions are available in the new laboratory of Oliver Billker (MIMS director from 1st October 2018). The projects are part of a major effort funded by the European Research Council to systematically identify parasite gene functions in malaria transmission.
All announcements are also found on: www.mims.umu.se
Postdoctoral Fellowship and PhD Student Opportunities in the lab of Barbara Sixt:
Molecular Infection Biology & Cell-Autonomous Immunity
The postdoc project involves the development and implementation of a CRISPR/Cas9 screening approach to dissect the molecular composition of a recently identified novel pathway of programmed cell death induced during infection with the obligate intracellular bacterial pathogen Chlamydia trachomatis.
Read more (Start: preferred September 2018)
Prospective PhD students are also encouraged to get in touch to discuss opportunities.
Postdoctoral Fellowship in the lab of Felipe Cava: Peptidoglycan Diversity and Plasticity in Bacteria
The open project focuses on a genome wide peptidoglycan profiling in the model bacterium Vibrio cholerae. You will perform state of the art UPLC-MS assays coupled to chemometric tools, live microscopy and transposon-sequencing screenings amongst other biochemical, cell and molecular biology techniques.
Read more (deadline 30 August 2018)
PhD Student in the lab of Andrea Puhar: Endogenous Danger Signals in Infection and Inflammation
The open project aims at understanding how the gut microbiota and enteric pathogens regulate the intestinal eATP concentration and how this impacts the development of disease. You will perform molecular microbiology work including transposon screens and mutagenesis in combination with biochemical assays, protein purifications and in vitro/in vivo infections.
Please contact Andrea Puhar, if you are interested by sending your CV and cover letter to firstname.lastname@example.org (Start date: as per agreement) Read more about the Puhar lab
Postdoc in the lab of MIMS Clinical Research Fellow Lisa Påhlman, Lund University:
Acute and chronic airway infections in cystic fibrosis (CF). The present project focuses on the CF pathogens Pseudomonas aeruginosa and Achromobacter xylosoxidans, with the aim to use molecular methods including genomics and cell infection models to characterise virulence factors involved in the establishment of acute and chronic airway infections. In particular, the role of Type 3 secretion and Twin-arginine translocation systems will be explored.
Read the complete advertisement (deadline 15 August 2018)
Postdoctoral Fellowships in Oliver Billker’s (https://billkerlab.org/) new research team: Experimental Genomics of Malaria Transmission. Prospective PhD students are also encouraged to get in touch. A range of projects are available:
- Systematic identification of fertility genes in malaria parasites. Using our unique ability to carry out forward genetics screens (Bushell et al., Cell, 2017), you will develop assays to identify experimentally all parasite genes involved in specific aspects of male or female fertility, which is essential for parasite transmission to the vector.
- Mechanisms of Plasmodium sex determination and sexual stage differentiation. Outgoing from a list of candidate nucleic acid binding proteins which have already emerged from a genetic screen, you will use ChIP, single cells RNAseq and protein interaction studies to elucidate the molecular mechanisms of development in a divergent eukaryote downstream of the master regulator, transcription factor ap2-g (Sinha et al., Nature, 2014).
- Single Cell Biology of Malaria Transmission. Using single cell transcriptomics (scRNAseq, e.g. Reid et al., eLife, 2018), you will carry out an in-depth analysis of developmental mutants, using their unique transcriptional signatures to propose genetic networks and mechanisms of parasite development during transmission.
- New Transmission Blocking Targets. The development of an effective vaccine to block malaria parasite infectivity to their mosquito vectors is considered a priority in ongoing efforts to eradicate malaria. Current targets undergoing clinical trials are all still from the pre-genomic era and pose significant challenges. With the advent of genetic screening technology in the rodent model parasite Plasmodium berghei (Bushell et al., 2017), it has now become possible for the first time to screen systematically for essential sexual stage antigens and evaluate their potential as future vaccine candidates.
- Mosquito Immunity. Our unpublished RNAseq analysis of thousands of single mosquito hemocytes has revealed new populations of immune cells of unknown function. You will use imaging and CRISPR-Cas9 mediated genome editing to reveal their roles in controlling insect immunity and vector competence.
- Evolution of sexual processes in a divergent eukaryote. You will exploit the position of malaria parasites in the tree of life to reveal the most conserved molecules in cellular processes involved in eukaryotic sexual reproduction, as well as discover some of the unique biology of apicomplexan parasites.
Detailed announcements on the website of Umeå University (Applications are possible until the positions are filled).
More about Oliver Billker's research (billkerlab.org)
About MIMS and Umeå University
The Laboratory for Molecular Infection Medicine Sweden, (MIMS, www.mims.umu.se), is the Swedish node in the Nordic EMBL Partnership for Molecular Medicine (www.embl.de/research/partnerships/remote/nordic/ and www.nordicemblpartnership.org).
MIMS consists of research groups with about 150 affiliated researchers including Postdocs, PhD students and Clinical Research Fellows. We follow the EMBL model for recruitment and evaluation of young group leaders and postdoctoral fellows and collaborate with EMBL and our Nordic Partners.
MIMS is established since 2007/2008 as a Research Unit with joint main support from the Swedish Research Council and Umeå University. It is integrated in the interdisciplinary research environment of Umeå Centre for Microbial Research (www.ucmr.umu.se), a consortium of scientists active in different areas of life sciences that promotes e.g. postdoctoral programmes and joint funding to sustain state-of-the-art research infrastructure (www.kbc.umu.se/english). MIMS groups hosted by the Department of Molecular Biology (www.molbiol.umu.se) are located in a unique interfaculty environment with research and teaching affiliation to the Faculty of Medicine and the Faculty of Science and Technology. The MIMS research groups are additionally supported by several national and international research funders, e.g. the Swedish Research Council, the European Research Council (ERC), the Knut and Alice Wallenberg Foundation and the Kempe Foundations.
Umeå University is dedicated to providing creative environments for learning and work. We offer a wide variety of courses and programs, world leading research, and excellent innovation and collaboration opportunities. Our research in infection biology, microbiology and molecular biology has a pronounced international profile. More than 4 100 employees and 32 000 students have already chosen Umeå University. We welcome your application!
Contact for general questions about MIMS:
Eva-Maria Diehl, Communication officer