Postdoc in molecular hematology with focus on acute leukemia
The Department of immunology, genetics and pathology at Uppsala University has a broad research profile with several strong research groups focused on e.g.. cancer, autoimmune- and genetic diseases. A fundamental idea at the department is to stimulate translational research and thereby closer interactions between medical research and health care. Research is presently conducted in the following areas: Medical and Clinical Genetics, Clinical Immunology, Pathology, Neuro-oncology, Vascular Biology, Radiation Sciences and Molecular Tools. Department activities are also integrated with the units for Oncology, Clinical Genetics, Clinical Immunology, Clinical Pathology and Hospital Physics at Uppsala University Hospital. The department has teaching assignments in several education programs, including Master Programs, at the Faculty of Medicine, and in a number of educations at the Disciplinary Domain of Science and Technology. The Department has a yearly turnover of around 400 million SEK, out of which more than half is made up of external funding. The staff amounts to approximately 340 people, out of which 100 are PhD-students, and there are in total more than 600 affiliated people.
The position as Postdoctor is in Dr. Linda Holmfeldt’s group at the Department of Immunology, Genetics and Pathology, Uppsala University, Swed. The research group focuses on studying acute leukemia using a combination of genomics, cell- and molecular biology techniques, and in vivo models.
Work description: The research project focuses on studies of mutations in the epigenetic regulator Polycomb repressive complex 2 (PRC2) that have been identified in analyses of pediatric acute lymphoblastic leukemia. The work includes detailed biochemical and cellular analyses combined with in vivostudies, to investigate the role of various PRC2 mutations within initiation and progression of leukemia. The work includes 100% research.
– Doctoral Degree in a for the project relevant subject. – Experience in standard molecular biology techniques such as nucleotide- and protein work. – The applicant should be able to design and execute experiments, following consultation with the supervisor.
– Excellent skills within written and oral communication in English. – Good teamwork skills.
– Previous experience in cell culture work.
– Experience of working with in vivo models and holding of a FELASA B certificate.
– Experience of bioinformatics, including analysis of next generation sequencing data.
– Experience of flow cytometry.
Start date: As soon as possible.
Form of employment: General temporary employment for 2 years.
Extent of employment: 100%