Postdoctoral Position in Membrane Protein Biochemistry

Lawrence, Kansas
NIH level, commensurate with experience
May 17 2018
Position Type
Full Time
Organization Type
Job Type

The Principal Investigator, Prof. Michael S. Wolfe, is internationally recognized as a founder of the field of intramembrane-cleaving proteases or I-CLiPs and a leader in the study of the molecular basis of Alzheimer’s disease.  Prof. Wolfe discovered presenilin as the catalytic component of the gamma-secretase complex, a membrane-embedded aspartyl protease involved in production of the amyloid-beta peptide of Alzheimer’s disease as well as signaling from the Notch family of receptors.  He recently moved to his alma mater, the University of Kansas, after 17 years at Harvard Medical School and has established a vigorous program to study substrate recognition and mechanism of action of this enzyme and its role in the pathogenesis of Alzheimer’s disease.  Prof. Wolfe has mentored over 30 postdoctoral fellows, and successful fellows have gone on to leading positions in academia and industry.

Job description and qualifications: The successful candidate will conduct research on protease biochemistry, biophysics, and molecular biology, specifically the study of I-CLiPs such as gamma-secretase.  Mutations in this membrane protease complex cause hereditary early-onset Alzheimer’s disease. The position will involve elucidation of substrate recognition and enzyme mechanisms and how these are altered by Alzheimer-causing mutations.  The position may also involve the study of related intramembrane proteases.  The successful candidate will be part of an interdisciplinary team working on interrelated projects involving chemistry, biochemistry, biophysics, and molecular and cell biology.  Candidates should have a PhD in the molecular biosciences and appropriate expertise as demonstrated by high-quality research publications.

Application procedure: Interested applicants should apply directly online at  The application should include:

  1. a cover letter detailing research experience and their specific interest in the research program of the Wolfe Lab;
  2. a curriculum vitae;
  3. a list of three references and their contact information (email address, phone number, departmental address)

The University of Kansas is an Equal Opportunity and Affirmative Action Employers, full policy

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