Postdoctoral Research Fellow – Chemical Engineering Research and Development

Rahway, NJ, US
May 07 2018
Organization Type
Requisition ID: POS000238

Merck & Co., Inc. Kenilworth, N.J., U.S.A. known as Merck in the United States and Canada, is a global health care leader with a diversified portfolio of prescription medicines, vaccines and animal health products. The difference between potential and achievement lies in the spark that fuels innovation and inventiveness; this is the space where Merck has codified its legacy for over a century. Merck’s success is backed by ethical integrity, forward momentum, and an inspiring mission to achieve new milestones in global healthcare.
Merck is on a quest for cures and is committed to being the world’s premier, most research-intensive biopharmaceutical company. Today, we’re doubling down on this goal. Merck Research Laboratories is a true scientific research facility of tomorrow, and will take Merck’s leading discovery capabilities and world-class small molecule and biologics R&D expertise to create breakthrough science that radically changes the way we approach serious diseases. 
Be a part of the legacy: MRL Postdoctoral Research Fellow Program The Merck Research Laboratories (MRL) Postdoctoral Research Fellow Program aims to be a best-in-industry program for industrial postdoctoral researchers, designed to provide you with an academic focus in a commercial environment. With the resources, reach, and expertise of a large pharmaceutical company, postdoctoral researchers will be positioned to excel in an institution committed to breakthrough innovation in research and discovery.
Position Overview: 
As a postdoctoral fellow in the MRL Chemical Engineering Research and Development Department based in Rahway, NJ, you will collaborate closely with a highly motivated cross-functional team of engineers and chemists to design, develop, and characterize continuous crystallization processes for the isolation of drug substance compounds.  Through experimental design and process modeling, you will develop new technologies and methodologies that are capable of producing crystals with desired physical properties, in some cases, generating tailored attributes not accessibly through batch processing.  This work will advance the field of continuous processing in the pharmaceutical industry as well as enhance the understanding of crystallization process development. Responsibilities include but are not limited to:
  • Designing, developing and performing batch and continuous crystallization experiments and characterizing these processes through a variety of in-line and off-line analytical tools.
  • Establishing an appropriate control strategy and optimizing crystallizations to achieve product with desired form, habit, and particle size distribution.  Techniques are expected to include evaluation of active control via feedback control and/or model-predictive control approaches.
  • Developing robust crystallization process models to understand and characterize the variables that impact crystal attributes.
  • Establishing an overarching strategy for design and scale up of robust continuous crystallization, with a focus toward start-up and shut-down procedures.  Multiple potential designs will be interrogated, including novel approaches to integrate crystallization with wetmilling to maximize the opportunity for tuning of product attributes.


Education Minimum Requirement:  
  •  PhD with less than 3 years of Postdoctoral Experience or achieved a  Ph.d by Spring/Summer of  2018 
Required Experience and Skills:
  • Working knowledge of key crystallization concepts such as supersaturation, growth and nucleation kinetics, and kinetic and thermodynamic driving forces.  
  • Demonstrated ability to develop well-controlled crystallization processes through antisolvent addition and/or temperature.  
  • Laboratory hands-on experience.
  • Data interpretation, manuscript preparation, publication and presentation of results.
Preferred Experience and Skills:
  • Proficient in process modeling software such as Matlab, gPROMs, or similar software.
  • Familiarity with a variety of process analytical tools, including focused beam reflectance measurement (FBRM), infrared (IR), and high pressure liquid chromatography (HPLC).
  • Familiarity with particle engineering technology and concepts, such as wet milling.
  • Experience with continuous process technology and concepts.matter the most in their lives.
 Our employees are the key to our company’s success.  We demonstrate our commitment to our employees by offering a competitive and valuable rewards program.  Merck’s benefits are designed to support the wide range of goals, needs and lifestyles of our employees, and many of the people that matter the most in their lives.
Merck is an equal opportunity employer, M/F/D/V – proudly embracing diversity in all of its manifestations. Former Military, Transitioning Service Members, National Guard & Reserves - We value your past and present service

Job: Post-Doctoral Fellow
Other Locations:
Employee Status: Regular
Number of Openings: 1
Shift (if applicable):
Hazardous Materials:
Company Trade Name: Merck

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