Post-Doctoral Research Fellow in Molecular Imaging
Description: Post-doctoral positions are available for investigators interested in imaging science to perform clinical translational research. The successful candidate will join a multi-disciplinary research team in the emerging field of molecular imaging at the University of Michigan. This highly collaborative group develops innovative imaging technologies for precision medicine. Projects focus on the development, characterization, and validation of peptides for clinical use as specific molecular probes for early detection and image-guided therapy of cancer. Projects focus on (1) use of sophisticated genomic tools to identify early targets that arise in cancer transformation, (2) development of peptide dimers to produce multivalent ligand-target interactions for improved binding performance and detection of early targets at low levels of expression, and (3) clinical translation of integrated imaging approach. High resolution endoscopic, confocal, multiphoton, ultrasound, and photoacoustic imaging systems will be used to study probe uptake in small animal models. We aim to perform real-time detection of pre-malignant mucosa (dysplasia) in the biliary tract, colon, esophagus, liver, pancreas, and stomach. FDA-regulated clinical studies will be performed to validate peptide performance in human patients in collaboration with academic physicians.
Requirements: Candidates with a Ph.D. in biochemistry, chemistry, molecular biology, structural biology, cell biology, genetics, microbiology, immunology, pharmacology, or related discipline are invited to apply. Experience with chemical synthesis, cell culture, microscopy, ELISA, PCR, RT-PCR, Western blot, immunohistochemistry, and immunofluorescence are desirable. Experience with handling of small animals, including mice and rats, is preferred.
Environment: The laboratory is located in the Biomedical Science Research Building (BSRB) between the University of Michigan Medical Center and the science campus. The BSRB houses the Center for Molecular Imaging (CMI) (www.med.umich.edu/msair), a state-of-the-art small animal imaging facility, that has instruments for performing real time imaging, including Olympus FV1000MPE twin multi-photon microscope with Spectra-Physics Deep See femtosecond lasers, Endra Nexus 128 photoacoustic tomography scanner, Edgewave diode pumped Q-switched Nd-YAG laser, Opotek Phocus laser with optical parametric oscillator (OPO), Ultrasonix SonixTablet ultrasound scanner, Xenogen IVIS Spectrum, 200, and 100 (Caliper) systems, LI-COR Pearl Trilogy NIR fluorescence imaging system, Siemens Inveon PET/CT, GE Healthcare integrated eXplore SpeCZT/CT 120, and Varian horizontal bore MRI systems (9.4, 7, and 3T). Clinical trials are conducted in the hospital Medical Procedures Unit.
The University of Michigan is committed to diversity and equality in education and employment, and is an ideal training ground for postdocs who want to further develop their skills in pursuit of a career in academia or industry.
Lab website: https://sites.google.com/a/umich.edu/wang_lab
Contact: CV and contact information should be submitted by email: Thomas D. Wang, M.D.,Ph.D., Professor of Medicine, H. Marvin Pollard Collegiate Professor of Endoscopy Research, University of Michigan, Ann Arbor, MI 48109-2200, Email: email@example.com