Associate Principal Scientist, Imaging Biomarkers

South San Francisco, CA, US
April 17 2018
Organization Type
Requisition ID: IMA000160

Merck & Co., Inc. Kenilworth, N.J., U.S.A. known as Merck in the United States and Canada, is a global health care leader with a diversified portfolio of prescription medicines, vaccines and animal health products. The difference between potential and achievement lies in the spark that fuels innovation and inventiveness; this is the space where Merck has codified its legacy for over a century. Merck’s success is backed by ethical integrity, forward momentum, and an inspiring mission to achieve new milestones in global healthcare.

Merck is on a quest for cures and is committed to being the world’s premier, most research-intensive biopharmaceutical company. Today, we’re doubling down on this goal. Merck Research Laboratories is a true scientific research facility of tomorrow, and will take Merck’s leading discovery capabilities and world-class small molecule and biologics R&D expertise to create breakthrough science that radically changes the way we approach serious diseases. 

Merck Research Laboratories South San Francisco, a wholly owned subsidiary of Merck and Co., is focused on driving discovery research. Our new multi-disciplinary discovery research site offers state-of- the-art resources to explore the most promising science combined with Merck’s world-class R&D expertise in small molecules and biologics. Located within the heart of the Bay area’s biomedical community, research conducted in our new laboratories spans exploratory biology through early clinical development and is an integral part of Merck’s powerful world-class network of drug and vaccine discovery. 

Our ability to excel depends on the integrity, knowledge, imagination, skill, diversity and teamwork of an individual like you. To this end, we strive to create a fast-paced, nimble and flexible environment of mutual respect, creativity, invention and teamwork. With access to Merck’s proven global R&D organization, you’ll have the opportunity to collaborate with talented and dedicated colleagues while developing and expanding your career. 

Merck is currently seeking a qualified in vivo imaging scientist within Translational Biomarkers located at our South San Francisco site, where the group focuses on preclinical imaging biomarker development of in-vivo models of human diseases using multi-modality imaging techniques (e.g. Ultrasound, Optical/Computerized tomography (CT), and magnetic resonance imaging (MRI))  You will be a part of Translational Biomarkers Department work on discovery and development of novel biomarkers for preclinical studies, early clinical research, and clinical trials across therapeutic areas.   

The successful candidate will be expected to work as part of a team using cutting edge optical imaging technologies to develop and validate imaging biomarkers in pre-clinical in-vivo models to interrogate disease biology and support drug discovery. Experience with a variety of imaging methodologies such as fluorescence & bioluminescent imaging and microCT is required. Working knowledge of experimental design, executing in vivo studies, and novel fluorescent probe development is essential. The ability to work effectively both independently and in a team environment is expected. 

Duties would include and not limited to the following: 

• Responsibility for the discovery and development of novel imaging biomarkers to support drug discovery and development 

• Coordination and execution of imaging studies to meet a demanding Discovery program schedule 

• Maintenance and upkeep of laboratory equipment used for imaging experiments 

• Accurate record keeping for notebooks, equipment logs and research reports 

• Presentation of research results to discovery, pre-clinical and clinical teams, including writing of manuscripts for submission to peer-reviewed journals 

• Collaboration with Imaging Department personnel, Discovery Biology program teams, and clinical scientists, as well as external research institutes or contract research organizations (CROs).


PhD degree in Biomedical Sciences with 5+ year of experience; or MS degree in Biomedical Sciences with minimum of 10 years of experience in industry or academia

Required Experience and Skills: 

• Minimum of (5) years hands-on experience with in-vivo imaging experiment design and execution

• Strong analytical skills and working knowledge of imaging processing and data analysis programming languages and/or software packages

• Relevant research experience in in vivo fluorescent/ bioluminescent imaging and working knowledge of other imaging modalities, such as ultrasound, MRI, PET/SPECT or CT 

• Ability to foster and drive research projects while working with multiple disciplinary teams in a matrix environment

• Ability to learn drug research and disease biology and develop appropriate imaging biomarker solutions to overcome challenges associated with drug discovery and development 

• Experience in collaborating with external academic research institutes or managing CROs  

Preferred Experience and Skills:

• Design, synthesis, and evaluation of novel fluorescent & bioluminescent probes 

• Strong academic record including publications in peer reviewed journals 

• Strong written and oral communication skills 

• Interpersonal skills necessary for working in a highly collaborative, cross-functional working environment 

• Ability to work independently

• Experience in mentoring junior scientists

Your role at Merck is integral to helping the world meet new breakthroughs that affect generations to come, and we’re counting on your skills and inventiveness to help make meaningful contributions to global medical advancement. At Merck, we’re inventing for life. 


If you need assistance and/or a reasonable accommodation due to a disability during the application or the recruiting process, please send a request to


Search Firm Representatives Please Read Carefully: 

Merck & Co., Inc. is not accepting unsolicited assistance from search firms for this employment opportunity.  Please, no phone calls or emails.  All resumes submitted by search firms to any employee at Merck via email, the Internet or in any form and/or method without a valid written search agreement in place for this position will be deemed the sole property of Merck.  No fee will be paid in the event the candidate is hired by Merck as a result of the referral or through other means.


Visa sponsorship is not available for this position.


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Job: Imaging
Other Locations:
Employee Status: Regular
Travel: Yes, 10 % of the Time
Number of Openings:
Shift (if applicable):
Hazardous Materials:
Company Trade Name: Merck

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