Postdoctoral position to investigate the polygenic basis of congenital heart defects

Irvine, California (US)
Salary negotiable, commensurate with training & experience; substantial additional benefits.
April 17 2018
Position Type
Full Time
Organization Type

The UC Irvine Center for Complex Biological Systems ( seeks a postdoctoral scholar to study the polygenic basis of congenital heart defects, and the transcriptional identity of heart stem/progenitor cells, in mouse models of mammalian heart development.  The position is fully funded and will be supervised by Professors Anne Calof and Arthur Lander.  Research will focus on how multiple small perturbations to gene expression collectively produce heart defects in multi-system birth defects disorders known as transcriptomopathies.

The successful applicant will have a Ph.D. in molecular and/or developmental biology, genetics, or genomics, and evidence of publication and/or preparation of high quality journal article(s). The applicant’s training should provide sufficient preparation to use mouse genetics, embryology, molecular biology, high resolution imaging (including optical projection tomography and MRI), together with genomics (RNA sequencing/bioinformatics), to identify morphogenetic abnormalities (progenitor cell proliferation, patterning and migration) and gene expression changes. Single-cell RNA sequencing of early embryos will also be used to identify transcriptional changes in individual progenitor cells.

The salary range for this position is negotiable and will be commensurate with training and experience; healthcare benefits are included. Appointment will initially be for a one-year period with extension for up to 4 years, subject to performance.

Please send inquiries about this position to:

Anne L. Calof, Professor, CCBS (

Arthur D. Lander, Professor and Director, CCBS (

Requirements for application:

To apply for this position, please submit the following to

  • Curriculum Vitae:  Your most recently updated CV
  • Cover Letter including Statement of Research
  • References:  2-3 letters of reference required

The University of California, Irvine is an Equal Opportunity/Affirmative Action Employer advancing inclusive excellence. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, protected veteran status, or other protected categories covered by the UC nondiscrimination policy.

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