Postdoctoral Fellow Opportunity in Cardiovascular Research (Washington University)
Postdoctoral Fellow Opportunity in Cardiovascular Research
Department Name/Job Location:
This opportunity is at Washington University School of Medicine in the Department of Internal Medicine – Division of Cardiology and located at CSRB – North Tower Addition on the Medical School Campus.
This opportunity is full-time. Hours are generally normal business hours but may vary due to the timing of experiments and other research activity deadlines.
The interest of this academic laboratory (PI: Babak Razani) is understanding the mechanisms of atherosclerosis, diabetes, obesity, and fatty liver disease with special emphasis on the roles of macrophages. We and others have shown that perturbations in cellular processes involving autophagy, lysosomes, and inflammasomes play a critical role in macrophage dysfunction and subsequent cardiometabolic disease (reviewed in Evans, et al Science Signaling 2017). Some of our relevant primary papers include (Sergin, et al Science Signaling 2016 and Sergin, et al Nature Communications 2017). The primary focus of the lab will be to understand the mechanisms by which these cellular processes affect metabolism, determine if their manipulation ameliorates metabolic disease, and translate our findings to develop novel therapeutics in human coronary artery disease, obesity, and insulin resistance.
These questions are being studied using a combination of molecular and cell biology approaches in mouse primary cells/cell-lines, mouse models, human monocytes/monocyte-derived macrophages, and induced pluripotent stem cell (iPSC)-derived macrophages.
Candidates with extensive prior experience in cell, molecular biology or related fields with a Ph.D. or M.D. degree are encouraged to apply.
1. Mammalian cell culture
2. Basic Microbiology skills
3. Experience with microscopy especially confocal/fluorescence microscopy
4. Proficiency in basic molecular biology techniques including DNA, RNA, protein isolation and purification, PCR, cloning, reverse transcription PCR, immunoblot, ELISA
5. Experience with immunocyto- and histo-chemistry, experience working with frozen and paraffin embedded tissue.
6. Experience with flow cytometry and immunology
7. Ability to handle mice, perform injections, harvest tissue
Salary will follow NIH guidelines and will be adjusted by achievement.
This opportunity is eligible for full-time benefits. Please visit our website at http://hr.wustl.edu to view a summary of benefits.
Applicant Special Instructions:
Please contact Dr. Babak Razani at firstname.lastname@example.org. Candidates must provide a current CV and 2 to 3 references that can be contacted directly by phone and/or email.