We are looking for two highly motivated postdoctoral fellows or one lab manager with strong team capabilities to work on innovative translational medicine projects. The Mennella laboratory is located in vibrant Toronto at the newly renovated research institute of The Hospital for Sick Children – Canada’s largest hospital-based child health. The laboratory is affiliated with the Biochemistry department at University of Toronto and it is amply funded by major Canadian funding agencies (CIHR, NSERC) as well as international organization and private foundations.
The Mennella laboratory main focus is to understand the cellular mechanisms of rare disease such as ciliopathies and microcephaly using cellular model and patients cells. We have developed a research program together with clinicians at SickKids that include projects aimed at 1. Characterization of new diseases at the molecular level; validation of novel genes identified in the clinic 2. Development of diagnostic based on imaging and 3. Development of therapies. To study centrosomes and cilia, we use a unique cross-disciplinary toolbox, combining super-resolution fluorescence imaging, advanced EM approaches (FIB-SEM), in vivo functional genomics and patients' cellular models. We have direct access in the laboratory to state of the art equipment - super-resolution microscopes, automated confocal spinning disc- and excellent facilities for 1. High-throughput chemical and imaging screens; 2. mouse and zebrafish KO animal generation; 3 Centre for structural biology; 4. Facs facility and collaborators for mass spectrometry screens etc. We have open opportunities for collaboration with companies such as Zeiss and Novartis.
web site: http://biochemistry.utoronto.ca/person/vito-mennella/
Here’s What You’ll Need:
- Ph.D. with outstanding technical training, high motivations and great publication record.
- Relevant experience, excellent written, verbal communications and problem solving.
- Strong background in imaging with emphasis on single molecule imaging techniques (PDF #1) or mechanistic cell biology with experience in stem cell/molecular biology/mouse models (PDF #2 or lab manager)
- Molecular biology skills: high throughput and advanced cloning methods preferred
- Interest, capacity and drive to learn new techniques (i.e. super resolution microscopy and mechanistic cellular biology)
- Experience with protein expression and purification from bacteria and mammalian system by FPLC and proteins is a plus
Employment Type: Temporary, Full-time (1 year-contract with possibility of renewal up to three years or more). Pay starting from 42,000 CDN first year. Fellowships available.
Start Date: As soon as June 1, 2018, until the position is filled