Exec. Dir, Biology -Discovery

South San Francisco, CA, US
April 06 2018
Life Sciences, Biology
Organization Type
Requisition ID: BIO005120

Merck & Co., Inc. Kenilworth, N.J., U.S.A. known as Merck in the United States and Canada, is a global health care leader with a diversified portfolio of prescription medicines, vaccines and animal health products. The difference between potential and achievement lies in the spark that fuels innovation and inventiveness; this is the space where Merck has codified its legacy for over a century. Merck’s success is backed by ethical integrity, forward momentum, and an inspiring mission to achieve new milestones in global healthcare.

Merck is on a quest for cures and is committed to being the world’s premier, most research-intensive biopharmaceutical company. Today, we’re doubling down on this goal. Merck Research Laboratories is a true scientific research facility of tomorrow, and will take Merck’s leading discovery capabilities and world-class small molecule and biologics R&D expertise to create breakthrough science that radically changes the way we approach serious diseases. 

TheProtein Sciences Department of MRL in Palo Alto/South San Francisco is seekinga dynamic and collaborative leader who can bridge the interface of discoverybiology and biologics.  The Executive Director, BiotherapeuticsDiscovery will lead a team of biotherapeutics experts with therapeuticarea focus and experience across immunology and oncology, cardiovascular andmetabolic disease, neurobiology, opthamology, and infectious disease.  The successful candidate provides a primary interfacebetween disease biology discovery groups and biotherapeutics discovery and willcontribute to translational strategy.  S/hewill be an active partner in early biologics discovery and will identify anddrive new opportunities across therapeutic areas in collaboration with biologydiscovery teams.   S/he will enableTIDVAL with assays and tools and promote project progression through aggressiveassessment of multiple approaches to establish the best therapeutic modalityfor target biology.  In collaborationwith biology teams, they will implement the necessary in vitro and in vivo assaysnecessary to select and optimize biotherapeutic candidates across alltherapeutic areas and work with Department leadership to assure theirsuccessful transition and progression into the development pipeline.  This leader will be responsible for ensuringthat biotherapeutics formats and discovery strategies are appropriate for thetarget biology.  The successful candidatewill work in close collaboration with other protein science functions toevaluate and advance therapeutic candidates. They will be part of the senior leadership team within Protein Sciencesand will contribute to strategy and prioritization across the Department. 


Anability to build and assess in vitroand in vivo disease models acrossmultiple therapeutic areas.  A deepunderstanding of the principles of biotherapeutics in relationship to diseasemodels.

Contributeexperience with multiple therapeutic modalities including therapeuticantibodies, small molecules, engineered proteins and protein-small moleculeconjugates.  

An ability to assess frommultiple opportunities and modalities, and prioritize/pursue those mostmeaningful to patient health. Willingness to explore novel modalities and uncharted biology.

Demonstratedability to enable discovery research through establishing  the tools and infrastructure necessary to explorenew biology.  Enabling of TIDVALactivities by creating unique resources.  Demonstratedcontributions to new targets and approaches. Open partnership between biology and platform technologies.

Ph.D. in immunology,pharmacology, or related biology area and 10+ years of leading projects andteams.  Must have an understanding of theunique aspects of complex/multi-functional protein therapeutics.  Strong preference for candidates withexperience with multiple therapeutic modalities.

Preferred Experience
Expertisein multiple therapeutic areas including: immunology, metabolic disease, cancer biology, neurobiology, infectiousdiseases and innate immunity.

Understandingof cytokine biology and their role in disease.

Engineering of Fc receptorproperties.

Your role at Merck is integral to helping the world meet new breakthroughs that affect generations to come, and we’re counting on your skills and inventiveness to help make meaningful contributions to global medical advancement. At Merck, we’re inventing for life. 


If you need assistance and/or a reasonable accommodation due to a disability during the application or the recruiting process, please send a request to staffingaadar@merck.com.


Search Firm Representatives Please Read Carefully: 

Merck & Co., Inc. is not accepting unsolicited assistance from search firms for this employment opportunity.  Please, no phone calls or emails.  All resumes submitted by search firms to any employee at Merck via email, the Internet or in any form and/or method without a valid written search agreement in place for this position will be deemed the sole property of Merck.  No fee will be paid in the event the candidate is hired by Merck as a result of the referral or through other means.


Visa sponsorship is not available for this position.


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Job: Biology-Discovery
Other Locations:
Employee Status: Regular
Number of Openings:
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Company Trade Name: Merck

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