Staff Scientist | Molecular Medicine | Keane Lai Lab

April 06 2018
Life Sciences
Position Type
Full Time
Organization Type
About City of Hope

City of Hope, an innovative biomedical research, treatment and educational institution with over 5,000 employees, is dedicated to the prevention and cure of cancer and other life-threatening diseases and guided by a compassionate, patient-centered philosophy.

Founded in 1913 and headquartered in Duarte, California, City of Hope is a remarkable non-profit institution, where compassion and advanced care go hand-in-hand with excellence in clinical and scientific research. City of Hope is a National Cancer Institute designated Comprehensive Cancer Center and a founding member of the National Comprehensive Cancer Network, an alliance of the nation's 20 leading cancer centers that develops and institutes standards of care for cancer treatment.

Requisition 13416

Staff Scientist | Molecular Medicine | Keane Lai Lab

Position Summary and Key Responsibilities:

A Staff Scientist position is available, within the Department of Molecular Medicine at the Beckman Research Institute of City of Hope, to identify novel molecular and cellular mechanisms of liver and pancreatic carcinogenesis. We seek applications from candidates with expertise in biochemistry, molecular biology, and cell biology, with strong interests in translational research utilizing mouse models of hepatocellular carcinoma (HCC) and pancreatic ductal adenocarcinoma (PDAC) as well as human tissues/cells. The environment of the Beckman Research Institute is highly collaborative and these projects will involve multiple interactions with other research groups and core laboratories across our Institution.

Candidates who have strong interest in translational research and appreciate the complexity of biological systems are particularly encouraged to apply. The ability to work independently, to participate in highly collaborative projects, and to contribute intellectually to the development of the research are requisites for the Staff Scientist position. The Staff Scientist will be responsible for drafting manuscripts, progress reports, and presenting research results internally as well as extramurally when needed.

For more information about the laboratory, please see our publications (e.g., Gastroenterology 2017, Cancers 2018

The Staff Scientist series is designed for career research professionals whose primary function is to support the research infrastructure and activities of the institution. Staff Scientists will bring special skills, knowledge and experience to research programs or institutional core laboratories. Individuals appointed as staff scientists will receive a one-year fixed-term contract.

Minimum Education and Skills Required for Consideration:

Candidates for this Staff Scientist position should have a Ph.D. and/or M.D. degree(s), and in-depth experience with the following: immunoblotting; immunoprecipitation, including protein immunoprecipitation (IP), protein complex immunoprecipitation (Co-IP), chromatin immunoprecipitation (ChIP), and RNA immunoprecipitation (RIP); RNA and DNA extraction and purification; RT-qPCR and qPCR and conventional PCR; RNA-Seq; gel electrophoresis; mouse models; mouse genotyping; primary cell culture; maintenance and propagation of cell lines; organoids; lentiviral and adenoviral transduction; luciferase-reporter assay; collection/processing of tissues for frozen sections, in situ hybridization, immunohistochemistry, and cell culture; and microscopy/imaging and computer cataloguing of data.

Candidates should be highly motivated individuals with the ability to work in a team environment and with good oral and written communication skills in English.

City of Hope is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, or status as a qualified individual with disability.

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