Senior Scientist - Applied Statistical Geneticist

Employer
Merck
Location
Boston, MA, US
Posted
April 04 2018
Discipline
Life Sciences, Biology
Organization Type
Pharma
Requisition ID: BIO005115

Merck & Co., Inc. Kenilworth, N.J., U.S.A. known as Merck in the United States and Canada, is a global health care leader with a diversified portfolio of prescription medicines, vaccines and animal health products. The difference between potential and achievement lies in the spark that fuels innovation and inventiveness; this is the space where Merck has codified its legacy for over a century. Merck’s success is backed by ethical integrity, forward momentum, and an inspiring mission to achieve new milestones in global healthcare.


Merck is on a quest for cures and is committed to being the world’s premier, most research-intensive biopharmaceutical company. Today, we’re doubling down on this goal. Merck Research Laboratories is a true scientific research facility of tomorrow, and will take Merck’s leading discovery capabilities and world-class small molecule and biologics R&D expertise to create breakthrough science that radically changes the way we approach serious diseases. 


Merck is dedicated to turning causal human genetics and biology into new, differentiated disease modifying therapies to improve the lives of patients across auto-immune, cardio-metabolic and neurodegenerative disease. To fulfill this mission the Quantitative Target Sciences (QTS) group in the Human Genetics and Pharmacogenomics Department (GpGx) is searching for a highly collaborative and inquisitive scientist to join an inter-disciplinary team to transform human disease genetic discoveries into testable therapeutic hypotheses. 


We are looking for an applied statistical geneticist or applied genetic epidemiologist with extensive experience in analyzing and interpreting human genetic data and its association with complex disease and quantitative phenotypes. The successful candidate will participate in the statistical design and analysis of human genetic studies including common variant association and rare variant association studies. The candidate should have a solid foundation in statistics and genetics, a strong work ethic and the ability to work independently. In addition, the candidate will work with a team of disease experts and biologists to help advance discovery and development programs. 


This position requires the ability to communicate complex data analysis and results in a clear, concise and appropriate level to biologists, clinicians and senior management.  The successful candidate will develop and leverage academic collaborations, public-private partnerships, data from clinical trials and publically available data for the purpose of target identification and validation. This position affords an amazing opportunity to collaborate with scientists from across the organization including biostatistics, epidemiology, chemical-biology, functional genomics, discovery biology and genetics.  This position provides a unique opportunity to harness the power and information from human genetics to support the development of novel therapeutics.


Qualifications

Education: 

  • PhD

Required: 

  • Statistical programming skills (R/MATLAB/SAS)
  • Programming/Scripting skills (Python/Perl/Shell/etc.)
  • Strong communication and collaboration skills


Preferred:

  • Knowledge of experimental design
  • Subject matter expertise in human disease biology
  • Management and analysis of large genetic studies (n > 10,000)
  • Knowledge of GWAS statistical genetics software (PLINK/MaCH/SHAPE-IT/IMPUTE2/HLA*IMP/METAL/EPACTS/EIGENSOFT/etc.)
  • Knowledge of next-generation sequencing statistical analysis (sample/variant QC, association analysis)
  • Knowledge of meta-analysis theory and analysis
  • Knowledge of modern summary statistic analysis (LD-score regression, summary co-localization, etc.)
  • Mendelian Randomization


Your role at Merck is integral to helping the world meet new breakthroughs that affect generations to come, and we’re counting on your skills and inventiveness to help make meaningful contributions to global medical advancement. At Merck, we’re inventing for life. 

 

If you need assistance and/or a reasonable accommodation due to a disability during the application or the recruiting process, please send a request to staffingaadar@merck.com.

  

Search Firm Representatives Please Read Carefully: 

Merck & Co., Inc. is not accepting unsolicited assistance from search firms for this employment opportunity.  Please, no phone calls or emails.  All resumes submitted by search firms to any employee at Merck via email, the Internet or in any form and/or method without a valid written search agreement in place for this position will be deemed the sole property of Merck.  No fee will be paid in the event the candidate is hired by Merck as a result of the referral or through other means.

 

Visa sponsorship is not available for this position.

 

For more information about personal rights under Equal Employment Opportunity, visit:

 

            EEOC Poster

            EEOC GINA Supplement 



Job: Biology-Discovery
Other Locations:
Employee Status: Regular
Travel: Yes, 10 % of the Time
Number of Openings:
Shift (if applicable):
Hazardous Materials:
Company Trade Name: Merck

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