Post-Doctoral Associate

St Jude Children's Research Hospital
Memphis, Tennessee
March 29 2018
Position Type
Full Time
Organization Type

Post-Doctoral Associate

Department of Surgery

St. Jude Children’s Research Hospital

St. Jude Children’s Research Hospital is a world-renowned institution that is recognized as one of the best places to work in the nation. As a premier center for research and treatment of childhood catastrophic diseases, we employ a diverse team of scientific and healthcare professionals dedicated to the promise of hope. Children from all 50 states and from around the world have come through the doors of St. Jude for treatment, and thousands more have benefited from our research.

The Yang Laboratory at St. Jude is seeking creative and highly motivated candidates for a fully supported postdoctoral fellowship studying the epigenetic alterations of solid tumors and leukemia. The major interests of the lab are to study how alterations of histone demethylases causes cancer progression and therapy resistance, and to develop novel treatments to target histone demethylases.

Primary Duties and Responsibilities:

  • Generate isogenic immortalized cell lines using CRISPR/Cas9 gene editing
  • RNA-seq, ChIP-seq, ATAC-seq, Hi-C
  • Generate leukemia or solid tumor models using conditional knockout and transgenic systems.
  • Establish Ex Vivo disease models and engraft patient-derived xenografts
  • Test the therapeutic efficacy of novel inhibitors using in vivo and in vitro cancer models.
  • Writing first author manuscript

Minimum Education

Successful applicants will have a Ph.D. in molecular biology, cell biology, cancer biology, genetics or a related field.

To succeed in this position, applicants must have a strong cell and molecular biology background and an interest in working with in vivo model systems. Applicants with expertise in genome editing, computational biology, and working with hematopoietic stem cells, flow cytometry, and genetic models are desirable.

Qualified applicants should apply for job 38503 at

Contact Information

Jun Yang Ph.D.

Assistant Member, Department of Surgery

St. Jude Children’s Research Hospital

262 Danny Thomas Place

Memphis, TN  38105