Research Associate in Bacterial Infection and Innate Immunity

Location
London (Central), London (Greater)
Salary
Salary Scale: £36,800 - £44,220 p.a.
Posted
March 26 2018
Position Type
Full Time
Organization Type
Academia

Research Associate in Bacterial Infection and Innate Immunity

MRC Centre for Molecular Bateriology and Infection

Department of Life Sciences

Salary Scale: £36,800 - £44,220 p.a.

South Kensington Campus

Job summary

Applications are invited for a Research Associate in bacterial infection and innate immunity to join the lab of Professor Gad Frankel at the MRC Centre for Molecular Bacteriology and Infection (CMBI) and the Department of Life Sciences at Imperial College London. 

Bacterial infections and antibacterial resistance pose a significant risk to human health. Accordingly, there is a need to complement the traditional drug discovery routes with the development of innovative approaches to treat bacterial infections, which minimise both selective pressure promoting the emergence of resistance and the impact on the endogenous microbiota. The development of effective and novel control measures requires a systematic understanding of the biology of the disease, particularly the complex interactions between bacterial pathogens and their hosts in the context of the microbiota. 

The focus of this project is the mouse pathogen Citrobacter rodentium, which serves as a model to study mechanisms of virulence and host responses to infection with human pathogenic E. coli (e.g. EPEC and EHEC). 

You will be expected to investigate host (e.g. metabolic and immune) and microbiome responses to infection in the context of the counter measured employed by the pathogen. This project is based on the following publications originated from the Frankel group: Cell Rep. 2017, 21:3381-3389; PLoS Pathog. 2017, 13:e1006706; Cell Metab. 2017, 26:738-752.e6; Mucosal Immunol. 2017, 10:602-612; Nat Protoc. 2016, 11:1851-76; Nat Commun. 2014, 5:5887; Nat Rev Microbiol. 2014,12(9):612-23.

Duties and responsibilities

The successful candidate is expected to perform experiments to a high standard. In particular, the candidate is expected to:

• Perform standard scientific techniques including profiling immune responses (FACS/ELISA), infection, as well as molecular and cell biology
• To analyse and present data for interpretation by others.
• To ensure the validity and reliability of data at all times
• To present findings to colleagues and at conferences.
• To write up the finding for submission to refereed journals
• To take responsibility for organising resources and effective decision making in support of research
• To perform research work that fulfils the requirements of the grant objective

Essential requirements

  •  A PhD degree (or equivalent) in Immunology, Microbiota, Bacterial infection, or Cell Biology of Infection.

Demonstrable experience in the following:

  • Cell biology of infection, cellular and molecular biology
  • innate immune responses to infection
  • Cell culture, transfection and microscopy (electron and fluorescent)
  • A strong record of data dissemination
  • A personal licence will be an advantage

Demonstrable knowledge in the following:

  • Statistical and image analyses
  • Pathogen host interactions

You must have experience of working in a team, the ability to develop and apply new concepts and have a creative approach to problem-solving. You must also have excellent verbal and written communication skills and be able to organise your own work with minimal supervision and prioritise in response to deadlines.

Further information

This is a full time, fixed-term position until 31st August 2020, in the first instance. 

To apply please visit: https://www.imperial.ac.uk/job-applicants/

*Candidates who have not yet been officially awarded their PhD will be appointed as a Research Assistant within the salary range £32,380 - £34,040 per annum

Informal enquiries can be made directly to Professor Gad Frankel, Tel +44 20 7594 5253; email: g.frankel@imperial.ac.uk .

Should you have any queries about the application process please contact Peggy Baker by email at peggy.baker@imperial.ac.uk .

For technical queries when applying online, please contact recruitment@imperial.ac.uk .

Committed to equality and valuing diversity, we are also an Athena SWAN Silver Award winner, a Stonewall Diversity Champion, a Disability Confident Employer and are working in partnership with GIRES to promote respect for trans people. 

The College is a proud signatory to the San-Francisco Declaration on Research Assessment (DORA), which means that in hiring and promotion decisions, we evaluate applicants on the quality of their work, not the journal impact factor where it is published. For more information, see https://www.imperial.ac.uk/research-and-innovation/about-imperial-research/research-evaluation/