Associate Principal Scientist, ADME

South San Francisco, CA, US
March 22 2018
Organization Type
Requisition ID: RES002101

Merck Research Laboratories South San Francisco, a wholly owned subsidiary of Merck and Co., is focused on driving discovery research.  Our new multi-disciplinary discovery research site offers state-of- the-art resources to explore the most promising science combined with Merck’s world-class R&D expertise in small molecules and biologics. Located within the heart of the Bay area’s biomedical community, research conducted in our new laboratories spans exploratory biology through early clinical development and is an integral part of Merck’s powerful world-class network of drug and vaccine discovery.  At Merck, we are inspired by the belief that a research-driven enterprise dedicated to scientific excellence can create medicines and vaccines that save and improve lives. Every employee is building on our proud legacy of scientific breakthrough. Our ability to impact the lives of patients worldwide depends on the integrity, creativity, humility and scientific acumen of our team. We are creating a diverse organization that is inspired by invention and founded on a culture of respect and collaboration. At Merck Research Labs South San Francisco, you’ll have the opportunity to expand your knowledge and skills through collaboration with talented and dedicated colleagues while advancing your career. This position will support Merck's drug discovery and early clinical development efforts in the Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism (PPDM) and specifically within the Absorption, Distribution, Metabolism and Excretion (ADME) group.  Responsibilities include and are not limited to the following:
  • Represent PPDM and ADME on Discovery Teams throughout all stages of discovery to build key structure-property relationships across multiple drug modalities
  • Design and execute studies utilizing in silico, in vitro and in vivo approaches to predict, understand, and optimize ADME properties of our therapeutics entering development
  • Contribute to development, execution, and fostering of translational Pharmacokinetic- Pharmacodynamic/Efficacy and other useful quantitative pharmacology applications on program teams in a discovery setting
  • Present analyses to teams and to teams and to management
  • Preparing documentation for regulatory submissions as part of early clinical development  
  • Working at Merck’s new multi-disciplinary discovery research site in South San Francisco, the candidate should be creative and have a passion for drug discovery as well as a track record of driving results and rapidly progressing from idea conception to in silico, in vitro, and in vivo evaluation.  As part of Merck’s emphasis on innovation, the successful candidate also will actively explore external (commercial and academic) opportunities in order to engage new technologies and approaches to drug discovery relevant to Merck’s drug discovery/development pipeline.
  • Must excel in a team environment, where they will also collaborate with discovery functions (eg, medicinal and computational chemistry, translational pharmacology, pharmaceutics, toxicology) and development functions (eg, early clinical pharmacology, process chemistry) in order to prepare early data sets that can be translated to early clinical development. 
  • Expected to effectively present their work at team meetings as well as promote Merck science through publications and presentations/lectures. 
  • The position reports to the local PPDM ADME Director in SSF. 
  • Qualifications

      Education and Work Experience Requirements:
    • Bachelor’s degree with a minimum of (12) years industry experience 
    • Master’s degree with a minimum of (8) years Industry experience
    • PhD with a minimum of (4) years Industry experience in a Pharmaceutical Preclinical Development or Discovery organization
    • Relevant subjects for highest degree include Pharmaceutics, Pharmaceutical Chemistry, Chemistry, Biochemistry, Pharmacology, Engineering, or related science
    Required Experience:
  • Strong leadership, interpersonal, communication, problem solving, and collaboration skills along with strengths in delivering results on firm deadlines in support of discovery/early development programs
  • Demonstrated disposition towards recognition in the field, creativity and innovation via a strong publication/presentation record
  • Experience in providing ADME support to drug discovery teams and guiding the optimization of small molecule therapeutics towards development candidates
  • Preferred Experience:
  • Experience in optimization of biologic and other modality therapeutics
  • Experience in computational ADME using modeling software
  • Experience in establishing Pharmacokinetic-Pharmacodynamic/Efficacy relationships using modeling software
  • Experience in serving on multidisciplinary project teams that span cardio-renal, metabolic, and/or ophthalmic areas

     The quality of our team is essential to our success. We are creating a new and innovative approach to rewarding our employees and establishing a comprehensive value proposition. Our competitive compensation program and benefits are designed to support the wide range of goals, needs and lifestyles of our employees, and the people that matter the most in their lives. If you need an accommodation for the application process please email us at  Merck & Co., Inc. Kenilworth, N.J., U.S.A. known as Merck in the United States and Canada, is a global health care leader with a diversified portfolio of prescription medicines, vaccines and animal health products.  Today, we are building a new kind of healthcare company – one that is ready to help create a healthier future for us all. 

    Job: Research Science
    Other Locations:
    Employee Status: Regular
    Travel: No
    Number of Openings: 1
    Shift (if applicable):
    Hazardous Materials:
    Company Trade Name: Merck

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