Postdoctoral Research Fellow- 2D-LC for Characterization of Biotherapeutics

Kenilworth, NJ, US
March 20 2018
Organization Type
Requisition ID: POS000246

Merck & Co., Inc. Kenilworth, N.J., U.S.A. known as Merck in the United States and Canada, is a global health care leader with a diversified portfolio of prescription medicines, vaccines and animal health products. The difference between potential and achievement lies in the spark that fuels innovation and inventiveness; this is the space where Merck has codified its legacy for over a century. Merck’s success is backed by ethical integrity, forward momentum, and an inspiring mission to achieve new milestones in global healthcare.
Merck is on a quest for cures and is committed to being the world’s premier, most research-intensive biopharmaceutical company. Today, we’re doubling down on this goal. Merck Research Laboratories is a true scientific research facility of tomorrow, and will take Merck’s leading discovery capabilities and world-class small molecule and biologics R&D expertise to create breakthrough science that radically changes the way we approach serious diseases. 
Be a part of the legacy: MRL Postdoctoral Research Fellow Program The Merck Research Laboratories (MRL) Postdoctoral Research Fellow Program aims to be a best-in-industry program for industrial postdoctoral researchers, designed to provide you with an academic focus in a commercial environment. With the resources, reach, and expertise of a large pharmaceutical company, postdoctoral researchers will be positioned to excel in an institution committed to breakthrough innovation in research and discovery.
Position Overview:
The Analytical Technology group within Biologics Downstream Process Development and Engineering (DPDE) is seeking a Postdoctoral Research Fellow to join our cross-functional team in Kenilworth, NJ. Primary responsibilities of this position will focus on the application of two dimensional liquid chromatography (2D-LC) for advanced process and product characterization of biotherapeutics. Additionally, the Postdoctoral Research Fellow will focus on evaluation and implementation of 2D-LC as a  new Process Analytical Technologies (PAT) to support both traditional and continuous manufacturing efforts for Biologics. The selected individual will have the opportunity to work with a wide array of scientists from across Merck Research Labs (MRL), Merck Manufacturing Division (MMD) and academic collaborators to make significant contributions towards Merck’s therapeutic protein pipeline, PAT and facility of the future development efforts. Responsibilities include but are not limited to:
  • Developing 2D-LC methodology for analytical characterization of biotherapeutics
  • Implementing platform 2D-LC methodology across Biologics Bioprocess Development and Clinical Manufacturing
  • Establishing 2D-LC as a large molecule PAT tool
  • Defining pathway for cGMP implementation of 2D-LC  


Education Minimum Requirement:   
  • PhD with less than 3 years of Postdoctoral Experience or achieved a  Ph.D. by Spring/Summer of  2018 
Required Experience and Skills:
  • Fundamental understanding of two dimensional liquid chromatography approaches (LC-LC, LCxLC, and sLCxLC)
  • Thorough knowledge of separations science
  • Experience with UPLC/HPLC analysis of proteins/biologics (SEC, Pro A, RP, IEX) 
  • Proficient with Empower and Chemstation software systems
 Preferred Experience and Skills:
  • Experience with Mass Spectrometry characterization of proteins (i.e. peptide mapping, intact mass, and reduced mass)
  • Applied knowledge of multivariate data analysis (MVDA) and Chemometrics
  • Knowledge of Process Analytical Technology (PAT) and Automation

Our employees are the key to our company’s success.  We demonstrate our commitment to our employees by offering a competitive and valuable rewards program.  Merck’s benefits are designed to support the wide range of goals, needs and lifestyles of our employees, and many of the people that matter the most in their lives. Merck is an equal opportunity employer, M/F/D/V – proudly embracing diversity in all of its manifestations. Former Military, Transitioning Service Members, National Guard & Reserves - We value your past and present service

Job: Post-Doctoral Fellow
Other Locations:
Employee Status: Regular
Number of Openings:
Shift (if applicable):
Hazardous Materials:
Company Trade Name: Merck

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