Postdoctoral Research Associate

The laboratory of Dr. Huiwang Ai (https://med.virginia.edu/ai-lab/) in the Center for Membrane and Cell Physiology at the University of Virginia is seeking a Post-Doctoral Research Associate. The mission of this research team is to engineer novel molecular imaging probes to peer into cells and brains to understand their communications. The team is looking for an individual with one of the following expertise:

1. Protein engineering. This individual will develop genetically encoded fluorescent and bioluminescent biosensors. Candidates must have a PhD or equivalent in hand by start date in Biochemistry, Chemistry, Molecular Biology or a similar field; Two or more first-author publications in reputable journals; ) more than 3 years of experience in phage display, yeast surface display, fluorescent proteins, directed enzyme/antibody evolution, gene editing, or viral engineering; more than 3 years of experiences in molecular cloning, gene library construction, and/or screening. Preferred qualifications are: experience in live-cell imaging (confocal, super-resolution, TIRF, etc.); experience in stem cell or cancer cell biology.

2. Neurobiology. This individual will apply genetically encoded fluorescent and bioluminescent biosensors for brain activity imaging. Candidates must have a PhD or equivalent in hand by start date in neurobiology or a similar field; One or more first-author publications in reputable journals; Demonstrated expertise in standard and advanced neuronal electrophysiology recordings and rodent surgical procedures. Preferred qualifications are: expertise in neurotransmission, neuromodulation, and GPCR-based signaling; experiences in mouse models, imaging and morphological analyses, and animal behavior experiments.

3. Molecular Biology, Cell Biology and Imaging. This individual will couple genetically encoded fluorescent biosensors with live-cell microscopy (confocal, super-resolution, TIRF, FLIM, etc.) for the understanding of redox and metabolic signaling in cancer and/or diabetes. Candidates must have a PhD or equivalent in hand by start date in Biochemistry, Cell Biology, Molecular Biology or a similar field; Two or more first-author publications in reputable journals; more than 3 years of experience in cell biology and fluorescence microscopy. Preferred qualifications are: experience in molecular cloning; experience in cancer cell biology, insulin signaling, or beta cell function; experience in microscopy instrumentation.

The successful applicant will perform high-profile, NIH-funded research in an interdisciplinary research group, which interacts closely with Departments of Molecular Biophysics & Biological Physics, Chemistry, and Biomedical Engineering, the Neuroscience Graduate Program, the UVA Cancer Center, and the UVA Charles O. Strickler Transplant Center.

The Post-Doctoral Research Associate will work independently and collaboratively under the guidance of Dr. Ai, spending approximately 90% of the time conducting experiments and analyzing data, 5% on training graduate students, and 5% on writing manuscripts and grants. It is expected that the Research Associates will report research progress regularly in lab and collaborative meetings, present results and solicit input at local, national, and international conferences in the form of posters or oral presentations, and prepare figures and text for manuscripts with the PI's input.

To apply visit https://jobs.virginia.edu and search for Posting Numbers 0622864, 0622862 or 0622861. Applicants should complete a candidate profile, and attach a cover letter (including a short statement of research interest), CV (including a publication list), and contact information for three references. The University of Virginia is an equal opportunity and affirmative action employer. Women, minorities, veterans, and persons with disabilities are encouraged to apply.