Principal Scientist – Metabolic Disease (Insulin Resistance/Obesity)

South San Francisco, CA, US
March 15 2018
Organization Type
Requisition ID: RES002100

Merck Research Laboratories South San Francisco, a wholly owned subsidiary of Merck and Co., is focused on driving discovery research.  Our new multi-disciplinary discovery research site offers state-of- the-art resources to explore the most promising science combined with Merck’s world-class R&D expertise in small molecules and biologics. Located within the heart of the Bay area’s biomedical community, research conducted in our new laboratories spans exploratory biology through early clinical development and is an integral part of Merck’s powerful world-class network of drug and vaccine discovery.  At Merck, we are inspired by the belief that a research-driven enterprise dedicated to scientific excellence can create medicines and vaccines that save and improve lives. Every employee is building on our proud legacy of scientific breakthrough. Our ability to impact the lives of patients worldwide depends on the integrity, creativity, humility and scientific acumen of our team. We are creating a diverse organization that is inspired by invention and founded on a culture of respect and collaboration. At Merck Research Labs South San Francisco, you’ll have the opportunity to expand your knowledge and skills through collaboration with talented and dedicated colleagues while advancing your career. We are looking for an outstanding and highly motivated scientist with an expertise in research on metabolic diseases in general, and insulin resistance, obesity in particular. A successful candidate is expected to exhibit a combination of in vitro and in vivo research experience and have demonstrated productivity as evidenced by (including but not limited to) publications, oral presentations at conferences, patents and strong connections with academic thought leaders. The candidate would be expected to have deep knowledge of the disease area and be able to propose new targets, design and execute on preclinical target ID and validation independently, create a line of sight to the target patient population, keeping in mind the target product profile from a payer perspective. The candidate will also be expected to create and manage academic collaborations, lead projects, mentor colleagues within the organization in absence of a direct reporting structure. Consistent with a startup theme and culture of the site, the candidate must get into the lab to get the work done including but limited to, helping colleagues and/or generating data.  The candidate must be enthusiastic, energetic, articulate and a team player.  Responsibilities include and are not limited to the following:
  • Propose novel targets and design experiments for target ID and validation
  • Lead early discovery projects. Develop and execute research operation plans
  • Propose and set up appropriate technology and platform based on the need of programs
  • Conduct experiments and generate data
  • Present results to project team and senior management
  • Supervise and train associates

Education / Work Experience Requirement:
  • Ph.D. in Biology or relevant areas with a minimum of (7) years’ industry experience
Required Experience:

  • Must have deep understanding and prior research experience in the field of metabolic diseases
  • Must have at least (1) of the following skill sets:
    • Development of in vitro assays for target biology and HTS and/or
    • Development of in-vivo models
  • Independent and self-motivated scientist
  • Strong written and verbal communication skills
  The quality of our team is essential to our success. We are creating a new and innovative approach to rewarding our employees and establishing a comprehensive value proposition. Our competitive compensation program and benefits are designed to support the wide range of goals, needs and lifestyles of our employees, and the people that matter the most in their lives. If you need an accommodation for the application process please email us at  Merck & Co., Inc. Kenilworth, N.J., U.S.A. known as Merck in the United States and Canada, is a global health care leader with a diversified portfolio of prescription medicines, vaccines and animal health products.  Today, we are building a new kind of healthcare company – one that is ready to help create a healthier future for us all.

Job: Research Science
Other Locations:
Employee Status: Regular
Travel: Yes, 5 % of the Time
Number of Openings: 1
Shift (if applicable):
Hazardous Materials:
Company Trade Name: Merck

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