Postdoctoral Associate, Tonegawa Lab

Location
Cambridge, Massachusetts
Salary
Commensurate with experience
Posted
March 14 2018
Ref
Job ID 15809
Position Type
Full Time
Organization Type
Academia
Job Type
Postdoc

Postdoctoral Associate, Tonegawa Lab

The Tonegawa Lab at MIT is seeking highly motivated postdoctoral researchers interested in studying brain mechanisms subserving learning and memory. The goal of our research is to understand what happens in the brain when a memory is formed, when a memory formed previously is recalled on subsequent occasions, the role of memory in decision making, and how external/internal factors, such as reward, punishment, attention, and emotional state, affect learning and memory.

For the past three decades, our lab has been developing state-of-the-art genetic approaches to uncover the role of individual genes (neurotransmitter receptors, enzymes, etc.), spatially restricted cell types (via the Cre-loxP system), and specific hippocampal-entorhinal neural circuits in learning and memory processes using mice. These highly specific genetic approaches combined with behavioral assays, in vitro electrophysiology by field and patch clamp recordings, in vivo electrophysiology by tetrodes and EEG, and in vivo optical imaging by two-photon microscopy have allowed us to link observed phenotypes with specific genetic manipulations. This research direction has been very informative in understanding brain mechanisms underlying mammalian behavior and cognition.

More recently, our lab has led the field in the localization, visualization, and modulation of memory engram cells (the physical correlate of memory) and their circuits through the combined use of transgenic and optogenetic methods, such as channelrhodopsin and halorhodopsin. Our engram technology has permitted manipulations of memory-associated cognitions and behaviors both in health (e.g., false memory inception) and neurological (e.g., early Alzheimer’s disease) or psychiatric (e.g., depression) diseases.

This position in the Tonegawa Lab is a unique opportunity for highly qualified and extremely motivated Ph.D. applicants to start their postdoctoral training in the neuroscience field of learning and memory. Experience in molecular genetics and neuroscience is preferred, but not necessary. We offer a supportive, collaborative, and creative environment.

Please submit your application through MIT’s careers page (https://careers.mit.edu), including cover letter, curriculum vitae, and the names and contact information of three references (including current or most recent PI).

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