Senior Scientist, NMR Spectroscopy
Merck & Co., Inc. Kenilworth, N.J., U.S.A. known as Merck in the United States and Canada, is a global health care leader with a diversified portfolio of prescription medicines, vaccines and animal health products. The difference between potential and achievement lies in the spark that fuels innovation and inventiveness; this is the space where Merck has codified its legacy for over a century. Merck’s success is backed by ethical integrity, forward momentum, and an inspiring mission to achieve new milestones in global healthcare.
Merck is on a quest for cures and is committed to being the world’s premier, most research-intensive biopharmaceutical company. Today, we’re doubling down on this goal. Merck Research Laboratories is a true scientific research facility of tomorrow, and will take Merck’s leading discovery capabilities and world-class small molecule and biologics R&D expertise to create breakthrough science that radically changes the way we approach serious diseases.
This position within the Screening and Compound Profiling Department at Merck Research Laboratories (Kenilworth NJ, USA) will support drug lead discovery, optimization and development through the application of BioNMR spectroscopy.
We are looking for a highly motivated scientist to join our Biophysics, BioNMR and Protein Production & Characterization group. This group supports a broad range of drug discovery and development efforts that include fragment-based NMR screening and lead discovery, and detailed studies of ligand-protein interactions. Our group also supports the discovery and development of therapeutic proteins. You will work with a highly collaborative team of scientists, using state-of-the-art equipment that includes 500, 600(2) and 800 MHz spectrometers and automation.
As a member of a multidisciplinary team, you will apply BioNMR based techniques to identify fragment hits to drug targets, characterize their binding interaction with the drug target using both established and novel BioNMR methods, and collaborate with this team to progress prioritized fragment hits into novel leads. Your work will also include the application of a wide range of BioNMR technologies to understand the binding of small molecules and biologics discovered though other screening platforms. The successful candidate will work closely with biologists and protein biochemists and will have access to automated cloning, expression and crystallization technologies.
Productive and collaborative interactions with other members of the global, cross-functional department are required. There is an expectation for periodic travel to other locations. Cooperative and collaborative use of internal expertise and resources will be essential to success. The position requires active interaction with the external scientific community to continually improve scientific understanding, including presentations at national or international meetings.
Consistently cited as a great place to work, Merck employs talented people who discover, develop, manufacture, and market a wide range of vaccines and medicines to address unmet medical needs.
Each of us is joined by an extraordinary sense of purpose — bringing Merck’s finest achievements to people worldwide.
- A Ph.D. degree in Biochemistry, Biophysics, Biology or related disciplines
- PhD degree training in BioNMR.
- Relevant experience in NMR spectroscopy
- Demonstrated experience in a broad range of BioNMR techniques and in the area of protein purification and handling
- Excellent communication skills (written, presentation, and oral) that enhance team-based progress is required. Application of those skills both within and outside the department to ensure the maximum understanding of program status for therapeutic area project teams and management is required.
- Demonstrated potential to develop project management skills and identify/develop new areas of scientific expertise in bioNMR.
- Ability to work effectively and flexibly within timelines.
- Ability to prepare peer-reviewed publications.
- Minimum of 1 year postdoctoral training in BioNMR.
- Experience in the use of BioNMR FBDD screening techniques and additional biophysical methods to study ligand-protein interactions
- Experience with biophysical and functional characterization methods (e.g. SPR, thermal shift and calorimetric assays) to guide construct design and optimization of solution conditions for successful structural outcomes.
- Experience with other structural techniques such as X-ray crystallography, electron microscopy and/or small-angle scattering.
Your role at Merck is integral to helping the world meet new breakthroughs that affect generations to come, and we’re counting on your skills and inventiveness to help make meaningful contributions to global medical advancement. At Merck, we’re inventing for life.
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Employee Status: Regular
Travel: Yes, 5 % of the Time
Number of Openings: 1
Shift (if applicable):
Company Trade Name: Merck