Postdoctoral Research Fellow - Lysosomes in Neonatal Enterocytes and their Pathologies
To investigate the role of specialized lysosomes in neonatal enterocytes and their pathologies. From birth to weaning, intestinal enterocytes have a specialized endolysosomal system for the uptake and intracellular digestion of milk nutrients. Impairment of these specialized lysosomes leads to neonatal intestinal pathologies (Remis et al., 2014, PLOS Genetics). We will be exploring this system in subcellular detail using mouse genetic models and enteroid cultures, as well as examining its potential role in intestinal pathologies of newborn humans using biopsies and enteroids. Comparative studies may also be pursued in epithelial hair cells of the inner ear (Wiwatpanit et al., 2018, J Neurosci.).
The positions will be supported by R01 HD086719 titled ““Lysosomes in neonatal enterocytes and their pathologies””
DESIRED SKILLS AND EXPERIENCE
The candidate we are looking for should have, or be near completion of, a doctorate with high quality publications, and relevant research experience such as with the cell biology of lysosomes and endosomes, intestinal enterocytes, enteroids or similar cultures, and mouse metabolism. This project represents a novel and expanding field of research with ample possibilities for the establishment of an independent career, ideally as a future principal investigator.
ABOUT THE EMPLOYER
Our lab (http://anoverosduggan.northwestern.edu/) investigates the role of ion channels and transcription factors in various epithelia, like those giving rise to the nervous system during development, those involved in nasal and auditory sensory transduction, and that formed by the unique enterocytes of the neonatal intestine. In particular, we have focused on lysosomal ion channels and found specialized lysosomes in mechanosensory hair cells of the inner ear as well as in neonatal enterocytes.
Please send CV with a list of three references and a statement of research interest in our lab to Dr. García-Añoveros at email@example.com.