Staff Scientist Core Managers for the Viral Vector and the Cryo-electron Microscopy Cores

Research Triangle Park, NC
commensurate with experience and accomplishments
February 28 2018
Position Type
Full Time
Organization Type

Department of Health and Human Services

National Institutes of Health

National Institute of Environmental Health Sciences

Division of Intramural Research

Research Triangle Park, North Carolina

Viral Vector Core Manager, Neurobiology Laboratory

Cryo-electron Microscopy Core Manager, Genome Integrity & Structural Biology Laboratory


The National Institute of Environmental Health Sciences (NIEHS), part of the National Institutes of Health (NIH), is seeking two candidates to fill the positions of Staff Scientist Core Managers for the Viral Vector (Neurobiology Laboratory) and the Cryo-electron Microscopy (Genome Integrity & Structural Biology Laboratory) Core facilities. The NIEHS is located in the Research Triangle Park (RTP), a world renowned academic research center in North Carolina and an area well known for its high quality of life.

Core facilities are centralized, shared research resources that provide access to instruments, technologies and services as well as expert consultation to scientific and clinical investigators within the Institute. The typical core facility is a discrete unit and has dedicated personnel, equipment, and space for operations.

Vacancy #NR-101-VVC: Viral Vector Core Manager, Staff Scientist - The primary task of the Viral Vector Core (VVC) Manager is to recommend, develop and/or implement innovative gene delivery methods to support the research needs of the investigators. The VVC Manager will work independently to import and implement novel viral technology, maintain state-of-the-art knowledge of the field, supervise personnel and daily operation of the Core, oversee budget and spending, develop collaborative projects, train staff and scientists in applications of viral technology, and be skilled in preparing scientific presentations and publications. The VVC currently packages and validates retro/lentiviruses, adenoviruses, adeno-associated viruses, Sindbis virus, Zika virus, respiratory syncytial virus, and G-deleted rabies viruses. Qualified candidates must be experts who are familiar with packaging and titering methods as they apply to each viral type that the Core offers. In addition, the incumbent is responsible for performing as well as training staff in biochemical techniques such as molecular cloning, genotyping, plaque/focus forming assays, flow cytometry, tissue culture, confocal microscopy, immuno-histochemistry, Western and Southern blots, binding assays and ELISAs.

Vacancy #NR-102-cryoEM: Cryo-electron Microscopy Core Manager, Staff Scientist - The newly established Cryo-electron Microscopy (Cryo-EM) Core is used to understand the structure and function of biological macromolecules and complexes to better understand and treat diseases. The Cryo-EM Core Manager will direct a small staff to facilitate the use of the Cryo-EM facility by NIEHS scientists. This individual must have experience managing the installation of state-of-the-art high resolution cryo-EM microscopes; 5 or more years of experience operating and maintaining cryo-EM microscopes, particularly instruments with automated or semi-automated multi-specimen loading systems; experience in optimization of specimen preparation and associated biochemical methods such as protein expression and purification; extensive experience in automated data collection for cryo-EM, both for high resolution single particle cryo-EM and tomography; extensive experience in setting up computing environments, including interfacing with high performance computing and development of automated image processing pipelines; demonstrated experience and expertise, as documented by peer-reviewed publications, in determining structures of macromolecular complexes at near atomic resolution using single particle cryo-EM and experience with cryo-EM tomography and sub-volume averaging; and extensive experience training individuals at the post-doctoral, graduate and undergraduate level. The Cryo-EM Core Manager must also maintain state-of-the-art knowledge of the field; supervise personnel and daily operation of the Core, oversee budget and spending; develop collaborative projects; train staff and scientists in cryo-EM fundamentals through workshops, journal clubs, and informal interactions; and be skilled in preparing scientific presentations and publications.


In addition to the aforementioned requirements, applicants for either position should have a Ph.D., M.D. and/or equivalent doctoral degree with at least 5 years of postdoctoral research/or equivalent experience in their field, be capable of independently designing experiments. Applications from women and under-represented minorities are strongly encouraged. Appointees may be U.S. citizens, resident aliens, or non-resident aliens with, or eligible to obtain, a valid employment-authorization visa.


The successful candidates for this position will be appointed at a salary commensurate with experience and accomplishments with full Federal benefits, including leave, health and life insurance, retirement, and savings plan (401K equivalent).

Equal Opportunity Employment:

Selection for these positions will be based solely on merit, with no discrimination for non-merit reasons such as race, color, religion, gender, sexual orientation, national origin, political affiliation, marital status, disability, age, or membership or non-membership in an employee organization. The NIH encourages the application and nomination of qualified women, minorities, and individuals with disabilities.

Foreign Education:

Applicants who have completed part or all of their education outside of the U.S. must have their foreign education evaluated by an accredited organization to ensure that the foreign education is equivalent to education received in accredited educational institutions in the United States. We will only accept the completed foreign education evaluation. For more information on foreign education verification, visit the National Association of Credential Evaluation Services (NACES) website. Verification must be received prior to the effective date of the appointment.

Reasonable Accommodation:

NIH provides reasonable accommodations to applicants with disabilities. If you require reasonable accommodation during any part of the application and hiring process, please notify us. The decision on granting reasonable accommodation will be made on a case-by-case basis.

How to Apply:

Applications for these positions will be accepted February 26, 2018 through March 28, 2018. Interested candidates should submit their curriculum vitae and a two-page statement of research interests and goals, as ONE (1) combined PDF to the Division of Intramural Research Search Committee at The application materials should describe your experience in the specific areas listed in the respective position description above. Please include your name and the proper vacancy number (either NR-101-VVC or NR-102-cryoEM) in the subject line of the email submission. In addition, applicants must arrange to have THREE (3) reference letters sent to Please request referees to include your name and the proper vacancy number (either NR-101-VVC or NR-102-cryoEM) in the subject line of their email. Incomplete applications or paper applications cannot be considered. For further information about the position, please contact Dr. Traci Hall at

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