The Lilly Diabetes and Complications Research organization has built a research team passionate about discovery and preclinical development of new therapeutics in the areas of Insulin Discovery. Our group works cross-functionally with the Incretin Discovery team, other Diabetes and Complications research groups and scientists from peptide chemistry, small molecule chemistry, ADME, and toxicology. We are looking to add to our group someone with an eagerness to learn and perform impactful research. You should have an understanding of development, validation, and implementation of in vitro cellular assays with which to develop new therapeutics. You should have skills in developing and conducting in vitro and cell-based receptor signaling and pharmacology assays pertaining to diabetes and metabolic diseases. Do you have these skills? Are you able to learn new assays to apply to research for a complicated disease state? Are you ready to join a dynamic group of scientists working to make an impact in the lives of our patients?Here are some of the responsibilities of this role:
- Design, validate and implement in vitro assays for novel insulin and glucagon therapeutics.
- Perform cell culturing including cell line generation (stable and transient transfection) and molecular biology/biochemistry techniques (e.g. gene expression profiling).
- Develop and perform assays in the area of insulin and glucagon signaling including fatty acid oxidation, de novo lipogenesis, insulin signaling assays in ELISA format (e.g. pIR, pAkt, and pMAPK).
- Perform in vitro assays requiring the use of radioactive isotopes.
- Advance understanding of the in vitro mechanism of action of insulin and glucagon.
- Critically evaluate data and troubleshoot.
- Function independently, work within an open lab environment and work within cross-functional project teams.
- Accurate record keeping, independent data analysis, and reporting of data in written and oral formats.
At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our 39,000 employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We're looking for people who are determined to make life better for people around the world.
- Bachelor's degree in biology or a closely related field with 2 years of laboratory research experience or Masters degree with research in applicable area
- Qualified candidates must be legally authorized to be employed in the United States. Lilly does not anticipate providing sponsorship for employment visa status (e.g., H-1B or TN status) for this employment position.
- Experience in development and validation of in vitro cellular assays, compound screening, and data evaluation especially in the area of insulin and glucagon pharmacology
- Demonstrated ability to work on cross-functional teams and projects
- Strong communication skills and experience presenting data in a team environment
- Experience contributing to regulatory documentation
- The position level will be commensurate with the candidate's experience.
- The position is governed by regulations including OSHA, OLAW and NRC — compliance to all applicable regulations is mandatory.
- Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status