Postdoctoral Research Scholar
Postdoctoral Scholar position available to work on Human gut derived commensal and autoimmune disease: University of Iowa, Iowa City, IA, United States
A postdoctoral position is immediately available in the Department of Pathology, University of Iowa Carver College of Medicine. The major goal of my research is to understand the interaction between gut microbiota, diet and immune response and their role in health and disease. My research program focuses on two interconnected themes: i) to understand the role of gut microbiome and metabolome in the etiopathogenesis of MS; and ii) test therapeutic efficacy of human gut derived bacteria in animal models of MS. We have recently reported the gut microbiota which are depleted or enriched in MS patients (Sci Rep 2016, Altmetric Score 267). Specifically, we have observed that Prevotella, Parabacteroides, and Adlercreutzia were depleted whereas Pseudomonas, Blautia, Dorea and Mycoplana were enriched in in patients with MS. To test our bedside to bench approach, we isolated Prevotella histicola belonging to genus Prevotella (bacteria depleted in MS patients) and tested its ability to modulate disease in a preclinical model (experimental autoimmune encephalomyelitis-EAE) of MS. We showed that P. histicola can suppress EAE in HLA-class II transgenic mice (Cell Reports 2017, Altmetric Score 288). We are particularly interested in the mechanism by which human commensal modulate systemic immune response in EAE model leading to development of tolerance. Candidates with a strong background in Immunology and/or microbiology, with hand-on experience in mouse model of autoimmunity, primary cell culture, bacterial culture, flow cytometry, and molecular techniques are encouraged to apply. Experience with gut microbiome sequencing and analysis is a plus but not necessary.
Required qualifications include PhD, or MD/PhD, good communication and writing skills in English.
Desirable qualifications include experience developing, analyzing genetic mouse models, microbial culture, cell culture, flow cytometry analysis, protein analysis, metagenomic sequencing plus analysis, and immunostaining.
Contact: Ashutosh K Mangalam, PhD
Department of Pathology
200 Hawkins Dr
Iowa City, IA 52242
Online Application: To apply for this position, please visit our website at https://jobs.uiowa.edu, and reference requisition #2949.
The University of Iowa is an equal opportunity affirmative action employer. All qualified applicants are encouraged to apply and will receive consideration for employment free from discrimination on the basis of race, creed, color, national origin, age, sex, pregnancy, sexual orientation, gender identity, genetic information, religion, associational preference, status as a qualified individual with a disability, or status as a protected veteran.