Postdoctoral Scientist - Computational Approaches to Design of Novel Biotherapeutics -181311

Ridgefield, Connecticut
February 23 2018
Position Type
Full Time
Organization Type

Postdoctoral Scientist - Computational Approaches to Design of Novel Biotherapeutics -181311

Boehringer Ingelheim is an equal opportunity global employer who takes pride in maintaining a diverse and inclusive culture. We embrace diversity of perspectives and strive for an inclusive environment which benefits our employees, patients and communities. 

Boehringer Ingelheim is currently seeking a driven and innovative Postdoctoral Scientist in Bispecific Antibodies to join our Biotherapeutics Discovery department located at our Ridgefield, CT facility.

As a Postdoctoral Scientist, you will be a primary driver of fundamental research and technology innovation in the area of Antibody Engineering and Biotherapeutics Discovery. In particular, we are recruiting for a creative computational scientist to enable development of computational workflows to identify and optimize Fabs, scFv and multispecifics. The ideal candidate for this position will be an independently driven computational biophysicist / biologist who can apply molecular modeling and simulation based approaches to simultaneously optimize molecular recognition, efficient heavy-light chain pairings, antibody developability properties, safety, and PK/PD in a synergistic manner. The scientist will be expected to initiate and publish research findings to internal and external scientific community.

As an employee of Boehringer Ingelheim, you will actively contribute to the discovery, development and delivery of our products to our patients and customers. Our global presence provides opportunity for all employees to collaborate internationally, offering visibility and opportunity to directly contribute to the companies' success. We realize that our strength and competitive advantage lie with our people. We support our employees in a number of ways to foster a healthy working environment, meaningful work, diversity and inclusion, mobility, networking and work-life balance. Our competitive compensation and benefit programs reflect Boehringer Ingelheim's high regard for our employees.

Duties& Responsibilities:

  • Provide molecular modeling and simulation based inputs to research plans directed at the understanding and design of biotherapeutics. 
  • Implement structure-based strategies to generate and optimize monoclonal, bispecific and multi-specific antibody formats and contribute to discovery processes.
  • Work with multi-disciplinary groups of experimentalists, including those involved in protein expression, purification, biophysical characterization and drug development.
  • Proficiently execute assigned tasks in bioinformatics, homology-based antibody modeling, molecular dynamics and Monte-Carlo simulations.
  • Establish an international reputation in area of expertise with publication and conference participation; represent BIPI as a scientific leader in field of expertise at both internal and national/international conferences, meetings and organizations.
  • Comply all applicable regulations, performing all work in a safe manner; maintain proper records in accordance with SOP’s and policies.
  • Contribute towards mentoring colleagues
  • Other tasks assigned by the mentor time to time

Desired Experience, Skills and Abilities:

  • Original thinking, high level of motivation, and ability to work independently as well as collaboratively
  • Demonstrated creativity and initiative in driving cutting edge research and good publication record
  • Demonstrated knowledge of Antibody/Protein Engineering, hands-on experience with  computer programming, molecular modeling, simulations and data analyses
  • Ability to collaborate with experimentalists and colleagues interested in molecular biophysics
  • Exceptional written and oral communication skills

Requirements Requirements

  • PhD degree in computational biophysics, chemical engineering, bioinformatics or related discipline with no more than 2 years of postdoctoral experience
  • Familiarity with scientific computing and at least one modern computer programming language such as Python, Perl or C.
  • Familiarity with MatLab or similar  mathematical modeling software package
  • Familiarity with Molecular modeling and simulation packages such as MOE, BIOVIA, Schrodinger, NAMD, Gromacs and Amber.
  • Strategic research planning ability and excellent written and oral presentation skills

Our Culture:

Boehringer Ingelheim is a different kind of pharmaceutical company, a privately held company with the ability to have an innovative and long term view.  Our focus is on scientific discoveries that improve patients' lives and we equate success as a pharmaceutical company with the steady introduction of truly innovative medicines.  Boehringer Ingelheim is the largest privately held pharmaceutical corporation in the world and ranks among the world's 20 leading pharmaceutical corporations.  At Boehringer Ingelheim, we are committed to delivering value through innovation.  Employees are challenged to take initiative and achieve outstanding results. Ultimately, our culture and drive allows us to maintain one of the highest levels of excellence in our industry.  Boehringer Ingelheim, including Boehringer Ingelheim Pharmaceuticals, Inc., Boehringer Ingelheim USA, Boehringer Ingelheim Animal Health USA, Inc., Merial Barceloneta, LLC and Boehringer Ingelheim Fremont, Inc. is an equal opportunity and affirmative action employer committed to a culturally diverse workforce - Minority/Female/Protected Veteran/Person with a Disability.  All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

Boehringer Ingelheim is firmly committed to ensuring a safe, healthy, productive and efficient work environment for our employees, partners and customers. As part of that commitment, Boehringer Ingelheim conducts pre-employment verifications and drug screenings.


Similar jobs

Similar jobs