Postdoctoral Fellow position available in Cancer Immunology/Imaging/Biophysics/Structural Biology NY

NYU School of Medicine
New York City, New York (US)
February 21 2018
Position Type
Full Time
Organization Type

Postdoctoral Fellow position available in Cancer Immunology/Imaging/Biophysics/Structural Biology NYU School of Medicine, New York.

A Postdoctoral Fellow position is available immediately in the laboratory of Dr. Michelle Krogsgaard at the Department of Pathology and NYUPerlmutter Cancer Center, NYU School of Medicine in New York to work on a project focused manipulating T cell immune responses to cancer while maintaining specificity to avoid autoimmunity and off-target toxicity, which is recognized as one of the most important and challenging areas for clinical cancer immunotherapy.

Our laboratory combine biophysical techniques including NMR spectroscopy, 2D affinity/force measurements, computational docking, imaging with chemical labeling and T cell functional studies to provide an overall signaling model involving the TCR-CD3 complex and associated proteins to understand the molecular basis for transmitting an activating signal in T cells. Identifying the molecular determinants of TCR-CD3 and other associated kinases interactions involved in initiation of T cell signaling forms the basis for design of novel therapeutics (synthetic TCRs, CARs, antibodies or small molecules) to strengthen or weaken these interactions to target specific disease conditions.

Interested candidates should have a recent PhD degree in Biology, Molecular Biophysics or related area. Experience in basic cellular immunology, molecular biology, structural and biophysical methods protein expression, tissue culture, in vivo mouse models and flow cytometry is an advantage but not required. The successful candidate is expected to be detail-oriented, highly organized, able to multitask, take initiative, start and complete projects; must be flexible and willing to function on a fast-paced and changing work environment; must be able to work with a variety of people with different backgrounds. Must be proficient in working with computers, MS Office, PowerPoint, and Excel.

The laboratory is located in the Smilow Research Center: , a new 13-story building with excellent research facilities on the NYU Medical School Campus located in midtown Manhattan.

Salary and benefits will be commensurate with experience. Interested applicants should forward a cover letter, current and future research interests (max 1 page), curriculum vitae and the names, telephone numbers and e-mail addresses of three references by email to:

Michelle Krogsgaard, Ph.D., Associate Professor
Department of Pathology and Perlmutter Cancer Cancer
NYU School of Medicine, New York
phone: +1 212 263 9266

Founded in 1841 and located in the heart of New York City, with its vibrant biomedical research community and unsurpassed cultural opportunities, NYU School of Medicine is an equal opportunity affirmative action employer. Women and minority candidates are strongly encouraged to apply.

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