Enzyme Production Leader

DNA Script
France (FR)
to define
February 15 2018
Physical Sciences
Position Type
Full Time
Organization Type

DNA Script in a nutshell:

DNA Script is a leading company in manufacturing de novo synthetic nucleic acids using an enzymatictechnology. The company aims at accelerating innovation in life science and technology through rapid, affordable,and high-quality DNA synthesis. DNA Script's approach leverages nature's billions of years of evolution insynthesizing DNA to set a new standard for how nucleic acids are made and accelerate the adoption of syntheticbiology across diverse disciplines such as biopharma, sustainable chemistry and data storage.To date, DNA Script has raised over 16 M€ of financing, mostly through equity funding brought by prestigiousplayers such as Illumina Ventures, Merck Ventures, Sofinnova Partners, Kurma Partners and Idinvest. Thecompany partners with leading institutions, in particular Institut Pasteur.

Position open at DNA Script:

DNA Script is looking for an enzyme production leader in order to ensure the production of DNA Script proprietaryenzymes: first for internal R&D use and in a latter stage for DNA production operation.The assignment will involve first implementing new production process, managing internal production team,identifying and managing partnership for better enzyme expression system & scale-up.You will be also responsible for the design, development and validation of enzyme production system andprocesses.

Opportunity and Challenges:

We are looking to assemble a team of best-in- class, innovative and passionate people gathering their talents andskills to achieve one goal: bring to the world the next ultimate tool in biotechnology.We offer the opportunity of joining a dynamic, international and highly skilled team of a high potential biotechstartup. We have put in place competitive benefits (salary, equity, healthcare, meal voucher and publictransportation) along with a unique opportunity to work in the heart of Paris.

Experience and Skills

Must Have

Enzyme production and purification bioprocesses

Bioprocess development for Bacteria

Fermenter culture operations and development

Enzyme purification operation and development

Bioprocess scale-up

QC methods for enzyme characterization

Skills and ability to deliver complex and large quantity

information into a synthetic and useful manner

Attention to details

Leadership skills

Good organizational skills

Insightful /results focused

Nice to have

Experience with different over-expression systems

Experience with secretion systems

Bioprocess development for Yeast

Bioprocess development for mammalian cells

Attraction to the start-up world


Holds a Master or PhD degree in the field of Biological Process Engineering, Chemical engineering, Biotechnology or similar.

Has +5 years of hands-on and industrial experience in protein production / purification and preferably upscaling of processes to industrial scale.

Job Types: Full-time, Permanent