Postdoctoral Fellow

Frederick, Maryland (US)
We offer competitive salary and comprehensive health insurance.
February 14 2018
Position Type
Full Time
Organization Type

Department of Health and Human Services (DHHS)

National Institutes of Health (NIH)

National Cancer Institute (NCI)

Center for Cancer Research (CCR)

A postdoctoral position is available in the Biomolecular Structure Section, Macromolecular Crystallography Laboratory, CCR, NCI, NIH, DHHS. The successful candidate will perform basic research, structural analysis of RNA-protein complexes, on the Frederick campus of NCI in Maryland, USA.

Our research is focused on the structural biology of RNA biogenesis, with an emphasis on RNA-processing proteins and RNA polymerase-associated transcription factors, and structure-based development of therapeutic agents. The goal of structural analysis is to map the reaction trajectory and/or functional cycle of selected biological macromolecules, and that of drug discovery is to design, synthesize, and characterize novel anticancer and antimicrobial agents. To date, we have characterized the reaction trajectory and/or functional cycle of HPPK (a folate pathway enzyme essential for microorganisms but absent in mammals), Era (an essential GTPase that couples cell growth with cell division), RapA (a Swi2/Snf2 protein that recycles RNA polymerase), bacterial RNase III, and yeast RNase III (Rnt1p). Several biomolecules mentioned above are attractive molecular targets and structure-based drug development is an integral part of our research.    

Interested candidates must have a Ph.D. and/or an M.D. and have less than 5 years of postdoctoral experience. Applicants must have a strong background in macromolecular crystallography and eukaryotic protein expression and working experience with RNA. The appointment will be one year initially and renewable up to a total of 3-5 years based on performance. The NIH is dedicated to building a diverse community in its training and employment programs. This position is subject to a background investigation. We provide an excellent work environment, state-of-the-art facilities, and regular access to synchrotron light sources. We offer competitive salary and comprehensive health insurance.

To apply, please submit application in a single PDF file, including a cover letter, a curriculum vitae with bibliography and contact information of three references, and reprints of 1-3 representative publications to Dr. Xinhua Ji at

DHHS, NIH, and NCI are Equal Opportunity Employers

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