Postdoctoral Fellowship in CRISPR-Cas Genome Engineering Technologies for Sickle Cell Disease

St Jude’s Children’s Research Hospital
Memphis, Tennessee
February 08 2018
Life Sciences, Genomics
Organization Type

Postdoctoral Fellowship in CRISPR-Cas Genome Engineering Technologies for Sickle Cell

Disease Therapeutics

Department of Hematology

St. Jude Children’s Research Hospital, Memphis, TN

The Tsai Laboratory is seeking highly motivated and creative candidates for a fully supported postdoctoral fellowship to advance potentially curative strategies to treat sickle cell disease by CRISPR-Cas gene editing of human hematopoietic stem cells.

You will have the opportunity to lead new projects such as:

  • Optimizing pre-clinical CRISPR-Cas gene editing strategies for induction of fetal hemoglobin in red blood cell progeny of edited human hematopoietic stem and progenitor cells
  • Developing improved genomic methods to define and measure genome-wide activity of genome editing nucleases
  • Protein engineering of CRISPR-Cas nucleases for precise gene correction

In this position, you will gain extensive experience and training in gene editing, protein engineering, and high-throughput genome biology.


Successful applicants will have a strong publication record, excellent communication skills, and a Ph.D. or equivalent degree in molecular biology, cell biology, genetics, genomics, hematology, or a related area. To succeed in this position, you will have a strong molecular and cell biology background, with an emphasis on molecular cloning and genetic manipulation of mammalian cells. Applicants with experience with human hematopoietic stem cells, genome editing, next-generation sequencing, or automated liquid handling are strongly encouraged to apply for job 37033 at


St. Jude Children’s Research Hospital, located in Memphis, Tennessee, is one of the world’s premier research and treatment centers for childhood disease. St. Jude has been recognized by Fortune magazine as one of the “100 Best Companies to Work For” every year since 2011 and was one of The Scientist’s top 10 “Best Places to Work in Academia” for seven consecutive years. St. Jude offers highly competitive stipends and benefits and actively fosters professional development. For more information, visit

St. Jude is an Equal Opportunity Employer.

Contact Information

Shengdar Tsai, Ph.D.

Assistant Member, Department of Hematology

St. Jude Children’s Research Hospital

262 Danny Thomas Place

Memphis, TN  38105