Postdoctoral Research Associates – Chemical Biology and Therapeutics

Memphis, Tennessee
February 06 2018
Life Sciences, Biology
Organization Type

Postdoctoral Research Associates – Chemical Biology and Therapeutics

St. Jude Children’s Research Hospital

Memphis, TN

The laboratory of Dr. Taosheng Chen studies the roles of nuclear receptors PXR and CAR in regulating drug-induced liver toxicity, tumorigenesis, and cancer drug resistance. We develop novel chemical probes/therapeutic leads by using a multidisciplinary approach (biology, chemistry and structural biology), and use them to interrogate the function of PXR and CAR in order to overcome drug toxicity, drug resistance and tumorigenesis in cellular and animal models (Lin et al, Nat Commun. 8:741, 2017).


The postdoctoral fellow will work on one of the projects:

(1) In vitro and in vivo validation of novel small molecule modulators of PXR and CAR in regulating drug metabolism, toxicity and resistance, and tumorigenesis (pharmacological approach);

(2) Regulation of PXR and CAR signaling pathways (multidisciplinary approach).

The successful candidate will work in a collaborative and multidisciplinary environment by collaborating with chemists and structural biologists (

Minimum Education:

Significant experience in one of the following areas is desirable: using animal models to study small molecules, cell and molecular biology, pharmacology. Candidates must have (or soon receive) a PhD or MD degree.  Highly motivated individuals (biologist or pharmacologist) with evidence of scientific accomplishment are encouraged to apply at

Contact Information:

Taosheng Chen, PhD

Member (Professor), Department of Chemical Biology and Therapeutics

St. Jude Graduate School of Biomedical Sciences

Director, High Throughput Bioscience Center

St. Jude Children's Research Hospital

262 Danny Thomas Place

Memphis, TN 38105-2794


Phone: 1-901-595-5937

Fax: 1-901-595-5715