Postdoctoral Position in Cancer Metabolism and Circadian Disruption

Location
Orange County, California
Salary
Negotiable
Posted
January 29 2018
Position Type
Full Time
Organization Type
Academia

Postdoctoral Position in Cancer Metabolism and Circadian Disruption

A postdoctoral position is immediately available within the Masri Lab at the University of California, Irvine (UC Irvine). The Masri lab employs a systemic approach to understanding cancer metabolism that is linked to the circadian clock, the biological pacemaker that regulates diurnal physiology. We are interested in two research questions. The first question relates to how genetic disruption of the circadian clock in mouse models alters tumorigenesis both at the level of initiation and disease progression. The second question is aimed at elucidating the systemic crosstalk between tumors and peripheral tissues and how cancer cells are able to rewire circadian metabolism at a distance.

We are seeking independent and motivated postdoctoral candidates interested in a multi-disciplinary approach to tumorigenesis including: cancer metabolism, circadian clock disruption, and transcription and epigenetic control. The Masri lab utilizes genetic mouse models, molecular and cell biology, as well as genome-wide ‘omics’ approaches to determine changes in gene expression programs, histone modifications, and alterations in metabolites using metabolomics. In addition, bioinformatics expertise is an advantage, but certainly not required. Experience with mouse handling and experiments, mammalian cell culture, and routine molecular and cell biology are needed. Also, at least 1 first author publication from the Ph.D. training period is required.

For more details about the Masri Lab, including relevant publications (Cell, 2014; Cell, 2016; PNAS, 2013; Science Signaling, 2014; Nature Neuroscience, 2010) please see: https://www.faculty.uci.edu/profile.cfm?faculty_id=6387

The Masri Lab is part of the Department of Biological Chemistry, Chao Family Comprehensive Cancer Center, and the Center for Epigenetics and Metabolism at UC Irvine. We are located in Southern California, between Los Angeles and San Diego. For further details about UC Irvine and Southern California, please see: https://uci.edu/

For consideration, applicants may send an email to Professor Selma Masri (Masrilaboratory@gmail.com) with the following information:

  • Brief statement of research interests and future goals
  • CV detailing research experience, publications, any fellowships obtained during the training period, and other relevant information
  • List of any manuscripts in preparation or currently under review
  • Names of 3 references that are familiar with the research experience of the candidate and can provide letters of recommendation upon request

UC Irvine is an equal opportunity employer and all qualified applicants will receive consideration for employment regardless of race, religion, gender, sexual orientation or identity, disabilities, or any other aspects protected by law.

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