Postdoctoral Research Fellow – Antibacterial Pharmacokinetics and Pharmacodynamics

Employer
Merck
Location
Upper Gwynedd, PA, US
Posted
January 19 2018
Discipline
Other
Organization Type
Pharma
Requisition ID: POS000247

Merck & Co., Inc. Kenilworth, N.J., U.S.A. known as Merck in the United States and Canada, is a global health care leader with a diversified portfolio of prescription medicines, vaccines and animal health products. The difference between potential and achievement lies in the spark that fuels innovation and inventiveness; this is the space where Merck has codified its legacy for over a century. Merck’s success is backed by ethical integrity, forward momentum, and an inspiring mission to achieve new milestones in global healthcare.
Merck is on a quest for cures and is committed to being the world’s premier, most research-intensive biopharmaceutical company. Today, we’re doubling down on this goal. Merck Research Laboratories is a true scientific research facility of tomorrow, and will take Merck’s leading discovery capabilities and world-class small molecule and biologics R&D expertise to create breakthrough science that radically changes the way we approach serious diseases. 
Be a part of the legacy: MRL Postdoctoral Research Fellow Program The Merck Research Laboratories (MRL) Postdoctoral Research Fellow Program aims to be a best-in-industry program for industrial postdoctoral researchers, designed to provide you with an academic focus in a commercial environment. With the resources, reach, and expertise of a large pharmaceutical company, postdoctoral researchers will be positioned to excel in an institution committed to breakthrough innovation in research and discovery.
Position Overview:
As a postdoctoral fellow in Pharmacokinetics, Pharmacodynamics and Drug Metabolism (PPDM) you will work with a highly collaborative team of scientists from antibacterial disease area biology, pharmacology, clinical, regulatory and scientific affairs. The aim will be to develop novel in vitro and mathematical modeling methodologies to assess how drug combinations may affect the PK/PD driver for anti-infectives with an initial focus on beta-lactamase inhibitors (BLIs), including internal BLI combinations ceftolozane/tazobactam and imipenem/relebactam. This work will be leveraged to influence emerging regulatory guidance and susceptibility breakpoint recommendations. 
Responsibilities include but are not limited to:
  • Generating high throughput static checkerboard in vitro data to various drug combinations with a large number of resistant bacterial strains to gain a mechanistic understanding of drug resistance 
  • Designing and executing dynamic hollow fiber experiments utilizing Merck’s own state of the art custom setup to understand antibacterial PK/PD 
  • Integrating the above generated data in a mathematical modeling framework to provide a greater degree of insight into fundamental characteristics of antibacterial exposure-response
  • Leveraging the computational modeling platform to provide a standardized and robust approach to deriving susceptibility testing criteria and justification of breakpoints  
Qualifications

Education Minimum Requirement: 
  • PhD with less than 3 years of Postdoctoral Experience or achieved a PhD by Spring/Summer of 2018 
Required Experience and Skills:
  • Experience in mathematical modeling of biological systems
  • Skills in conducting experiments to assess the pharmacology of infectious disease agents
  • Understanding of basic pharmacokinetics and pharmacodynamic principles
Preferred Experience and Skills:
  • Experience in pharmacological characterization of antibacterials, including execution of time-kill in vitro studies
  • Strong history of publication in peer-reviewed journals
  • Skills in at least one of the following: NONMEM, R, Matlab, or similar tools
Our employees are the key to our company’s success.  We demonstrate our commitment to our employees by offering a competitive and valuable rewards program.  Merck’s benefits are designed to support the wide range of goals, needs and lifestyles of our employees, and many of the people that matter the most in their lives. Merck is an equal opportunity employer, M/F/D/V – proudly embracing diversity in all of its manifestations. Former Military, Transitioning Service Members, National Guard & Reserves - We value your past and present service
mrlpostdoc

Job: Post-Doctoral Fellow
Other Locations:
Employee Status: Regular
Travel:
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Company Trade Name: Merck

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