Postdoctoral Research Fellow – Formulation Development & Delivery of Novel Vaccines

Boston, MA, US
January 19 2018
Organization Type
Requisition ID: POS000239

Merck & Co., Inc. Kenilworth, N.J., U.S.A. known as Merck in the United States and Canada, is a global health care leader with a diversified portfolio of prescription medicines, vaccines and animal health products. The difference between potential and achievement lies in the spark that fuels innovation and inventiveness; this is the space where Merck has codified its legacy for over a century. Merck’s success is backed by ethical integrity, forward momentum, and an inspiring mission to achieve new milestones in global healthcare.
Merck is on a quest for cures and is committed to being the world’s premier, most research-intensive biopharmaceutical company. Today, we’re doubling down on this goal. Merck Research Laboratories is a true scientific research facility of tomorrow, and will take Merck’s leading discovery capabilities and world-class small molecule and biologics R&D expertise to create breakthrough science that radically changes the way we approach serious diseases. 
Be a part of the legacy: MRL Postdoctoral Research Fellow Program The Merck Research Laboratories (MRL) Postdoctoral Research Fellow Program aims to be a best-in-industry program for industrial postdoctoral researchers, designed to provide you with an academic focus in a commercial environment. With the resources, reach, and expertise of a large pharmaceutical company, postdoctoral researchers will be positioned to excel in an institution committed to breakthrough innovation in research and discovery.
Position Overview: 
The Discovery Pharmaceutical Sciences group at Merck Research Labs in Boston, MA is actively recruiting a postdoctoral fellow to develop novel formulations for the delivery of next-generation mucosal vaccines. The postdoc will design and develop novel formulations intended to overcome the physiological barriers associated with mucosal delivery and maximize the efficiency of antigen delivery using a combination of in vitro and in vivo assays. For this multidisciplinary project, the postdoc will work with a creative, collaborative team of motivated scientists from diverse fields, including pharmaceutical science, immunobiology, vaccines/infectious disease biology, and microbiome research.
Responsibilities include, but are not limited to, the following:
  • Development and physicochemical characterization of vaccine formulations suitable for mucosal administration, with a focus on oral delivery
  • Development of small-scale in vitro screening techniques to predict formulation performance
  • Formulation iteration and optimization based on in vivo performance in murine models
  • Independent experimental design, execution, and troubleshooting
  • Effective collaboration on a multidisciplinary team
  • Data analysis and written and oral presentation of results
  • Manuscript preparation and publication
  • Contribution to a safe and compliant laboratory work environment


Education Minimum Requirement:
  • PhD in chemistry, chemical engineering, biological engineering, pharmaceutical science, biochemistry, or related field with fewer than 3 years of postdoctoral experience, or graduate student anticipating meeting all the requirements of a PhD by spring/summer of 2018

Required Experience and Skills:
  • Experience in formulation development and advanced drug delivery technologies, with an emphasis on particle-based or targeted delivery systems
  • Very strong analytical skills and experience in physicochemical characterization techniques such as liquid chromatography, light scattering, microscopy, and spectrophotometric assays 
  • Understanding of oral absorption and GI physiology in humans and relevant preclinical species
  • Superior verbal & written communication skills
  • An excellent record of academic achievement, including publications in peer-reviewed journals
  • Strong personal character and ethics 

Preferred Experience and Skills:
  • Good working knowledge in the field of immunology or vaccinology
  • Development of immuno-stimulatory formulations
  • Hands-on experience in microbiology, biochemistry, or molecular/synthetic biology

A cover letter and a letter of reference from your current research advisor are encouraged; you may attach these with your CV/resume.
Our employees are the key to our company’s success.  We demonstrate our commitment to our employees by offering a competitive and valuable rewards program.  Merck’s benefits are designed to support the wide range of goals, needs and lifestyles of our employees, and many of the people that matter the most in their lives. Merck is an equal opportunity employer, M/F/D/V – proudly embracing diversity in all of its manifestations. Former Military, Transitioning Service Members, National Guard & Reserves - We value your past and present service

Job: Post-Doctoral Fellow
Other Locations:
Employee Status: Regular
Number of Openings:
Shift (if applicable):
Hazardous Materials:
Company Trade Name: Merck

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