Postdoctoral Research Fellow – Isotopic Tracer-Based Translational Safety Biomarker Develop...

Employer
Merck
Location
West Point, PA, US
Posted
January 19 2018
Discipline
Other
Organization Type
Pharma
Requisition ID: POS000242

Merck & Co., Inc. Kenilworth, N.J., U.S.A. known as Merck in the United States and Canada, is a global health care leader with a diversified portfolio of prescription medicines, vaccines and animal health products. The difference between potential and achievement lies in the spark that fuels innovation and inventiveness; this is the space where Merck has codified its legacy for over a century. Merck’s success is backed by ethical integrity, forward momentum, and an inspiring mission to achieve new milestones in global healthcare.
Merck is on a quest for cures and is committed to being the world’s premier, most research-intensive biopharmaceutical company. Today, we’re doubling down on this goal. Merck Research Laboratories is a true scientific research facility of tomorrow, and will take Merck’s leading discovery capabilities and world-class small molecule and biologics R&D expertise to create breakthrough science that radically changes the way we approach serious diseases. 
Be a part of the legacy: MRL Postdoctoral Research Fellow Program The Merck Research Laboratories (MRL) Postdoctoral Research Fellow Program aims to be a best-in-industry program for industrial postdoctoral researchers, designed to provide you with an academic focus in a commercial environment. With the resources, reach, and expertise of a large pharmaceutical company, postdoctoral researchers will be positioned to excel in an institution committed to breakthrough innovation in research and discovery.
Position Overview: 
As a postdoctoral fellow in Merck Research Labs, Safety Assessment and Laboratory Animal Resources (SALAR) group based in West Point, PA, you will work with a highly collaborative team of scientists to expand SALAR’s capabilities in the use of stable isotopic tracers in vivo and in vitro to elucidate the alterations in fundamental biochemistry underlying mechanisms of liver toxicity. The learnings from this project would enable the pragmatic application of these tracers as translational biomarkers of drug-induced toxicities, helping to ensure patient safety.  Responsibilities include but are not limited to:
  • Design of in vivo and in vitro metabolic tracer studies to address specific mechanistic questions relevant to drug safety.  This may include use of emerging experimental model systems, including but not limited to genetic knock-out or knock-down models.
  • Quantification of stable labeled tracers in biological samples by LC-MS or other appropriate techniques
  • Data interpretation, manuscript preparation, publication and presentation of results
  • Contribute to a safe and compliant laboratory work environment
Qualifications

Education Minimum Requirement:  
  • PhD with less than 3 years of Postdoctoral Experience or achieved a  PhD by Spring/Summer of  2018 
 Required Experience and Skills:
  • Pharmacokinetic, pharmacodynamics or metabolic flux data analysis and interpretation experience
  • LC-MS operation and method development experience
  • Strong background in biochemistry
  • Excellent writing, verbal communication and collaborative skills
 Preferred Experience and Skills:
  • Mechanistic toxicology, especially the role of transporters in liver toxicology
  • Biomarker development
  • Stable isotope enrichment analysis
  • In vivo study design preferable
  • Mechanistic in vitro study design also desirable

Our employees are the key to our company’s success.  We demonstrate our commitment to our employees by offering a competitive and valuable rewards program.  Merck’s benefits are designed to support the wide range of goals, needs and lifestyles of our employees, and many of the people that matter the most in their lives. Merck is an equal opportunity employer, M/F/D/V – proudly embracing diversity in all of its manifestations. Former Military, Transitioning Service Members, National Guard & Reserves - We value your past and present service
mrlpostdoc

Job: Post-Doctoral Fellow
Other Locations:
Employee Status: Regular
Travel:
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Hazardous Materials:
Company Trade Name: Merck

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