Postdoctoral Research Fellow – Discovery Immuno-Oncology

Boston, MA, US
January 19 2018
Organization Type
Requisition ID: POS000226

Merck & Co., Inc. Kenilworth, N.J., U.S.A. known as Merck in the United States and Canada, is a global health care leader with a diversified portfolio of prescription medicines, vaccines and animal health products. The difference between potential and achievement lies in the spark that fuels innovation and inventiveness; this is the space where Merck has codified its legacy for over a century. Merck’s success is backed by ethical integrity, forward momentum, and an inspiring mission to achieve new milestones in global healthcare.
Merck is on a quest for cures and is committed to being the world’s premier, most research-intensive biopharmaceutical company. Today, we’re doubling down on this goal. Merck Research Laboratories is a true scientific research facility of tomorrow, and will take Merck’s leading discovery capabilities and world-class small molecule and biologics R&D expertise to create breakthrough science that radically changes the way we approach serious diseases. 
Be a part of the legacy: MRL Postdoctoral Research Fellow Program The Merck Research Laboratories (MRL) Postdoctoral Research Fellow Program aims to be a best-in-industry program for industrial postdoctoral researchers, designed to provide you with an academic focus in a commercial environment. With the resources, reach, and expertise of a large pharmaceutical company, postdoctoral researchers will be positioned to excel in an institution committed to breakthrough innovation in research and discovery.
Position Overview:  
As a postdoctoral fellow in the Merck Research Laboratories Discovery Oncology Department you will work with a highly collaborative team of scientists focused on Immuno-Oncology basic research and development. You will work on conceiving, designing, planning and implementing advanced experiments that will enable the delivery of innate immune agonists (including but not limited to STING and RIG-I agonists) to discrete subsets of cells in the tumor microenvironment (TME) upon systemic delivery of encapsulated, targeted liposomes. You will focus on the characterization of liposome compositions in vitro and their biodistribution upon different routes of delivery in vivo, and on the understanding of the pharmocodynamic effects and anti-tumor efficacy they induce in syngeneic tumor-bearing mice. 
Responsibilities include but are not limited to:  
  • Designing and characterizing liposome formulations that are ‘decorated’ with a specific targeting moiety and encapsulated with innate immune agonists (including but not limited to STING and RIG-I agonists)
  • Collaborating with Merck and external scientists to establish mouse in vivo syngeneic tumor models suitable to readily monitor anti-tumor efficacy and safety 
  • Immunophenotyping and ex vivo functional assessment of the lymphoid, myeloid and non-immune cell components present in the tumor microenvironment of tumor-bearing mice.
  • Data interpretation, manuscript preparation, publication and presentation of results
  • Contribute to a safe and compliant laboratory work environment

Education Minimum Requirement: 
  • PhD with 3 years or less of postdoctoral experience or met all the requirements for a PhD by Spring/Summer of  2018
Required Experience and Skills:
  • Skilled in  in vivo models in one or more of the following therapy areas:
    • immunology, immuno-oncology, infectious diseases or autoimmune diseases
  • Experience in flow cytometry 
  • Experience  in cellular immunology
  • Ability to independently design experiments, interpret and track results, and utilize this information to enable assay development
Preferred Experience and Skills: 
  • Experience with nanoparticle or liposome formulation design, delivery and in vivo characterization
  • Bioanalytical experience, ELISA, Luminex, MSD, RNAseq, Signal transduction techniques, ELISPOT, WB
  • Experience in innate immune cell and myeloid cell biology
  • Strong history of publication in peer-reviewed journals

Our employees are the key to our company’s success.  We demonstrate our commitment to our employees by offering a competitive and valuable rewards program.  Merck’s benefits are designed to support the wide range of goals, needs and lifestyles of our employees, and many of the people that matter the most in their lives. Merck is an equal opportunity employer, M/F/D/V – proudly embracing diversity in all of its manifestations. Former Military, Transitioning Service Members, National Guard & Reserves - We value your past and present service

Job: Post-Doctoral Fellow
Other Locations:
Employee Status: Regular
Number of Openings: 1
Shift (if applicable):
Hazardous Materials:
Company Trade Name: Merck

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