Postdoctoral Fellow - Epigenetics Laboratory of Hong Wen VARI

Van Andel Research Institute
Van Andel Research Institute is located in downtown Grand Rapids, MI, 2nd largest city in Michigan
Postdoctoral Pay Range is $47,500 - $54,000 plus full benefits, vacation, and retirement plans
January 18 2018
Position Type
Full Time
Organization Type

A postdoctoral position is available immediately in Dr. Hong Wen’s laboratory in the Center for Epigenetics at Van Andel Research Institute.

The Wen lab is interested in understanding epigenetic regulation of chromatin and transcription during normal and cancer development. The long-term goal of the lab is to understand the molecular mechanisms by which histone modifications regulate chromatin and transcription, and how dysregulation of histone modification homeostasis leads to human cancer.  Following early discoveries on seveal epigenetic readers (Wen and Li et al, Nature, 2014, Li and Wen et al, Cell, 2014; Wan and Wen et al, Nature, 2017), the current focus of the lab is to use cutting-edge technologies including CRISPR-Cas9 mouse models to elucidate the function of histone methylation and acetylation in the regulation of transcription elongation. The candidate postdoc will have opportunity to work on functional characterization of epigenetic regulators using CRISPR mouse models, development of novel epigenetic inhibitors, or discovery and characterization of novel epigenetic regulators in transcription elongation.

Specifically, we are interested in candidates with a background in mouse genetics, drug development and epigenetics.


  • A Ph.D. or M.D./Ph.D. in biochemistry, molecular and cell biology or similar research fields.
  • Experience with mouse models and knowledge of drug development are preferred.
  • A strong record of high-impact peer-reviewed publications is highly desirable.
  • Must provide the names of three individuals who can provide recommendations and present a scientific seminar describing his or her previous research.


    Description of a Successful Candidate:

  • A self-motivated and driven individual who is able to exhibit exceptional research productivity and take responsibility for independent management of the project.
  • A detail-oriented researcher that thinks critically to effectively design experiments and solve complex research problems.
  • A strong ability to take initiative and work independently, as well as in a team environment.
  • A collaborative, hands-on researcher who proactively shares knowledge and expertise with lab members.
  • Excellent written and oral communication skills.

Van Andel Research Institute (VARI) provides postdoctoral training opportunities to scientists beginning their research careers. The fellowships are to help promising scientists advance their knowledge and research experience and at the same time support the research endeavors of VARI under the mentorship of a VARI Faculty member.

While this project is currently funded, an integral part of postdoctoral training is the process of preparing a research proposal and writing a fellowship application. All VARI Postdoctoral Fellows are encouraged to apply for external funding as soon as it is practical and reasonable after hire. Receiving a fellowship award provides recognition for both the fellow and VARI!

Application Process:

Qualified applicants should provide a cover letter outlining research experience and interests, a curriculum vitae, and the names and address of three references to, or by visiting    

If you possess these attributes and desire to help us drive science from the bench to the clinic; while benefiting from a highly generous compensation package; we would welcome speaking with you and encourage you to apply today.


VAI is actively striving to diversify its workforce and strongly encourages qualified individuals from underrepresented groups to apply. Van Andel Institute is an EEO and Affirmative Action Employer.

This position will be open until filled. If you have any difficulty uploading your application or any questions, please email Eric Miller at


About Van Andel Research Institute

Van Andel Research Institute (VARI), the research division of VAI, is dedicated to determining the epigenetic, genetic, molecular and cellular origins of cancer, Parkinson’s and other diseases and translating those findings into effective therapies. The Institute’s scientists work in on-site laboratories and participate in collaborative partnerships that span the globe.


VARI Vision: Expand the growing global recognition for our trans-formative model of fundamental and translational research across the scientific continuum, expediting the application of novel investigator-led ideas to impact human health.


Vision in Action: In practice, we are world leaders in cancer epigenetics and Parkinson’s disease research. Collaborating with academia, industry, and philanthropy, we orchestrate cutting-edge clinical trials to improve human health.


VARI Culture: We strive to work as an effective team through close cooperation and communication in a spirit of trust and mutual respect. Research, education, and operations are interdependent, striving to improve team harmony.


About Grand Rapids, MI

Van Andel Research Institute is located in downtown Grand Rapids, MI which is the second largest city in Michigan and the largest city in West Michigan. Grand Rapids offers a remarkable combination of cosmopolitan atmosphere and small-town warmth, known for its philanthropic and sustainability-driven community, and is ranked one of "America's Top 100 Places to Live."

Located on the banks of the Grand River, Grand Rapids offers all the big-city excitement you'd expect from a million-resident metropolis, featuring hundreds of restaurants and nightspots, theaters, museums, sports and concerts. The safe and clean downtown is surrounded by an eclectic mix of walkable neighborhoods.