Postdoctoral Fellow - Diabetes and Metabolism Research Institute - Zeng Lab

Duarte, California
January 18 2018
Requisition 12422
Life Sciences
Position Type
Full Time
Organization Type

About City of Hope

City of Hope, an innovative biomedical research, treatment and educational institution with over 5,000 employees, is dedicated to the prevention and cure of cancer and other life-threatening diseases and guided by a compassionate, patient-centered philosophy.

Founded in 1913 and headquartered in Duarte, California, City of Hope is a remarkable non-profit institution, where compassion and advanced care go hand-in-hand with excellence in clinical and scientific research.  City of Hope is a National Cancer Institute designated Comprehensive Cancer Center and a founding member of the National Comprehensive Cancer Network, an alliance of the nation’s 20 leading cancer centers that develops and institutes standards of care for cancer treatment.

Requisition 12422

Postdoctoral Fellow - Zeng Lab

Position Summary and Key Responsibilities:

One postdoctoral fellow position is available for ambitious applicants to investigate regulation of autoimmunity in type 1 diabetes by immune check points and mixed chimerism. Successful candidates will have PhD or MD/PhD degree in biology, Immunology or related disciplines, and strong scientific backgrounds as evidenced by their publication record. Experience with the tools in molecular biology and animal models is a plus.

The Zeng laboratory is in the Diabetes and Metabolism Research Institute (DMRI)  and the Hematologic Malignancy and Hematopoietic Cell transplantation Institute, the Beckman Research Institute, City of Hope National Medical Center.  One of the major program in the Zeng Lab is to develop effective regimen for prevention of type 1 diabetes (T1D) and develop curative therapy for established T1D. We are actively collaborating with Dr. Arthur Riggs, the DMRI director, in making reagents that can effectively activate PD-1 and CD80 on activated pathogenic T cells to induce their tolerance. Dr. Riggs is a member of National Academy of Science and the inventor of recombinant insulin and the technology for making humanized antibodies. If you want to know more about the Zeng publications, please check Applicants should contact Dr. Defu Zeng at

Representative recent lab publications (selected from more than 60).

  1. Deng, R., C. Hurtz, C. Yue, G. Xiao, H. Yu, M. Muschen, P.  Martin, D. Zeng.  Extra-follicular CD4+ T-B Interactions are sufficient for induction of Autoimmune-like Chronic Graft-Versus-Host Disease (Nature Communications, 2017; 8: 978).
  2. Ni, X., Q. Song, K. Cassady, H. Jin, R. Deng. X. Song, S. Forman, P. Martin, J. Wang, and D. Zeng. PD-L1 interact with CD80 to regulate graft versus leukemia activity of donor CD8+ T cells (JCI 127: 1960-1977, 2017, featured article).
  3. Wu, L., N. Li, M. Zhang, A. Riggs, D. Zeng. Induction of MHC-mismatched mixed chimerism augments thymic Treg production and cures EAE (PNAS 2015; 112:15994-9).
  4. Wang, M., Racine, J., Song, X., Li, X., Nair, I., Liu, H., Avakian-Mansoorian, A., Shen, C., Atkinson, M., Todorov, I., Kandeel, F., Forman, S., Willson, B., D. Zeng. (2012). Mixed chimerism and growth factors augment beta cell regeneration and reverse late-stage Type 1 Diabetes (Sci. Transl. Med. 4, 133ra59, cover story)
  5. Zhang, C., I. Todorov, C. Lin, M. Atkinson, F. Kandeel, S. Forman, and D. Zeng. Elimination of insulitis and augmentation of islet β cell regeneration via induction of chimerism in overtly diabetic NOD mice. PNAS, 2007; 104:2337-2342.   (Faculty 1000 publication)    

Minimum Education and Skills Required for Consideration:

• A Ph.D. degree in life or biomedical sciences, or a related discipline is required.

City of Hope is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, religion, color, national origin, sex, sexual orientation, gender identity, age, status as a protected veteran, or status as a qualified individual with disability.

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