A NIH-funded post-doctoral position is available in the laboratory of Susan J. Baserga, MD, PhD, in the Departments of Molecular Biophysics and Biochemistry, Genetics, and Therapeutic Radiology. The successful candidate will be driving research into the mechanistic biochemical and physiological aspects of how ribosomes are made in eukaryotic cells using model systems ranging from Saccharomyces cerevisiae and Xenopus tropicalis, to mammalian cell lines and mice. The successful candidate will not only gain extensive experience working in these model systems, but will also receive expert career mentoring, and develop skills in a wide range of basic biochemical and genetic techniques including, but not limited to, northern blots, western blots, qPCR, subcellular fractionation, co-immunoprecipitation, immunofluorescence and RNA-seq.
Ribosome biogenesis is essential for cells and developing organisms. As such, ribosome production is often dysregulated in cancer and is implicated in a growing number of congenital human genetic diseases known as the ribosomopathies. We have also recently uncovered strong evidence to support a role for the nucleolus and ribosome biogenesis in embryonic development, neurodegenerative diseases, cytoskeletal integrity, and DNA repair, among other cellular processes and diverse signaling pathways (Cell Reports, in press). The successful candidate will conceptualize and design original research among these themes and execute it in an environment that values teamwork, camaraderie, and intellectual curiosity.
Candidates must be highly-motivated and have a PhD in the biological sciences, with a degree in biochemistry, genetics, cancer biology, developmental biology, or cell biology preferred. A high level of proficiency in basic laboratory techniques is also required.
For more information about the Baserga laboratory please visit our website at https://basergalab.yale.edu/. If you are interested in this position, please send your CV and cover letter to Dr. Susan J. Baserga at Basergalabapplications@gmail.com.