Postdoctoral Research Scientist/Fellow Positions

New York City, New York
Commensurate with Experience
January 10 2018
Position Type
Full Time
Organization Type

Postdoctoral Research Scientist/Fellow Positions

Postdoctoral positions are available to study mechanisms of epigenetic inheritance and cancer epigenetics at Columbia University’s Institute for Cancer Genetics. Candidates who have a solid background in molecular biology and biochemistry and are highly self-motivated in research are encouraged to apply. Experiences in yeast, mouse, and human cancer cells are preferred for these positions.

Interested candidates should email their CV and the names of three references to

Dr Zhiguo Zhang at:

and submit an online application to:


Our first long-term goal is to determine how epigenetically determined chromatin states are inherited during S phase of the cell cycle. Toward this goal, we have been using the budding yeast, mammalian cell culture, and mouse as models to address this fundamental, but poorly understood, process. Our second long-term goal is to elucidate how epigenetic alterations contribute to tumorigenesis using brain tumors as models. Detailed info about our lab can be found online at


  1. Fang D, Gan H, Lee J, Han J, Wang Z, Riester SM, Jin L, Chen J, Zhou H, Wang J, Zhang H, Yang N, Bradley EW, Ho TH, Rubin BP, Bridge JA, Thibodeau SN, Ordog T, Chen Y, van Wijnen AJ, Oliveira AM, Xu R, Westendorf JJ, Zhang Z (2016). The histone H3.3K36M mutation reprograms the epigenome of chondroblastomas. Science, 352: 1344–1348. Gan H, Yu C, Devbhandari S, Sharma S, Han J, Chabes A, Remus D, Zhang Z (2017). Checkpoint kinase Rad53 couples leading and lagging strand DNA synthesis under replication stress. Mol Cell, 68: 446–455. H, Gan H, Wang Z, Lee JH, Ordog T, Wold M, Ljungman M, Zhang Z (2017). RPA interacts with HIRA and regulates H3.3 deposition at gene regulatory elements in mammalian cells. Mol Cell, 65: 272–284. Han, J, Zhang H, Zhang H, Wang Z, Zhou H, Zhang Z (2013). A Cul4 E3 ubiquitin ligase regulates histone hand-off during nucleosome assembly. Cell, 155: 817–829.


Eligible candidates must have an MD and/or PhD degree in one of the following: Biochemistry, Molecular Biology, Genetic or Cancer Biology. Strong competence in yeast, mouse ES cells, and human cancer cells; a record of productive and collaborative research; and excellent communication skills in written and spoken English are required.

Columbia University is an equal opportunity/affirmative action employer—race/gender/disability/veteran.


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