Senior Scientist – ADME and Translational Pharmacokinetic / Pharmacodynamic Modeler
Merck & Co., Inc. Kenilworth, N.J., U.S.A. known as Merck in the United States and Canada, is a global health care leader with a diversified portfolio of prescription medicines, vaccines and animal health products. The difference between potential and achievement lies in the spark that fuels innovation and inventiveness; this is the space where Merck has codified its legacy for over a century. Merck’s success is backed by ethical integrity, forward momentum, and an inspiring mission to achieve new milestones in global healthcare.
Merck is on a quest for cures and is committed to being the world’s premier, most research-intensive biopharmaceutical company. Today, we’re doubling down on this goal. Merck Research Laboratories is a true scientific research facility of tomorrow, and will take Merck’s leading discovery capabilities and world-class small molecule and biologics R&D expertise to create breakthrough science that radically changes the way we approach serious diseases.
This position will support Merck's drug discovery and early clinical development efforts within the ADME group of the Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism (PPDM). The primary role of the successful candidate will be to develop, execute and foster translational Pharmacokinetic Pharmacodynamic (TPKPD) and other useful quantitative pharmacology applications on program teams in a discovery setting. The candidate will be expected to serve as a representative in multi-disciplinary teams providing expertise, guidance and hands-on support for the application of quantitative pharmacology sciences to address key questions and issues. The candidate will also be expected to support various internal and/or external scientific initiatives, such as the development and application of novel physiologically-based pharmacokinetic (PBPK) approaches.
Knowledge of drug metabolism sciences (ADME - Absorption-Distribution-Metabolism-Excretion) and pharmacodynamics are required. Responsibilities will also include presenting analyses to governance committees as well as preparing documentation for regulatory submissions.
- MS in biopharmaceutics, pharmaceutical sciences, pharmacometrics, computational biology/chemistry, or a related field with an additional 4+ years of relevant pharmaceutical industry experience
Ph.D. in biopharmaceutics, pharmaceutical sciences,pharmacometrics, computational biology/chemistry, or a related field Obtainedon or before June 2018 with relevant pharmaceutical industry experience
- Strong scientific background in pharmacokinetics, pharmacodynamics and drug metabolism (ADME) sciences
- Excellent communication, problem solving and leadership skills
- Experience and proficiency using modeling software such as Phoenix, simCYP, Matlab, NONMEM, etc.
- Experience in serving on multidisciplinary project teams
Your role at Merck is integral to helping the world meet new breakthroughs that affect generations to come, and we’re counting on your skills and inventiveness to help make meaningful contributions to global medical advancement. At Merck, we’re inventing for life.
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Job: Pharmacokinetics/Drug Metab
Employee Status: Regular
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Shift (if applicable):
Company Trade Name: Merck