Biological validation of the stem cells product into bioreactor to use in clinical therapy.
- Employer
- Università degli Studi di Genova
- Location
- Italy
- Posted
- November 16 2017
- Discipline
- Life Sciences, Biology
- Position Type
- Full Time
- Organization Type
- Academia
The mesenchymal stem cells (MSCs) are in advance clinical testing for a number of indications and are entering clinical use for the repair and regeneration of a range of damage tissue and organs. The expansion of MSC to clinical therapy need of a scalable, automated and fully closed process. The overall objective of our project is to develop and validate a closed, aseptic automated system for the manufacture of therapeutic stem cells.
In this project we will implement the: i) in vitro characterization of the cell product to determine identity, purity, potency; ii) in vitro investigation of the cell secretome for verification of trophic therapeutic factors and their therapeutic potential; iii)in vivo ectopic validation of cell product in a subcutaneous mouse model and diabetic mouse fracture repair mode, respectively.
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