Biological validation of the stem cells product into bioreactor to use in clinical therapy.

Employer
Università degli Studi di Genova
Location
Italy
Posted
November 16 2017
Discipline
Life Sciences, Biology
Position Type
Full Time
Organization Type
Academia

The mesenchymal stem cells (MSCs) are in advance clinical testing for a number of indications and are entering clinical use for the repair and regeneration of a range of damage tissue and organs. The expansion of MSC to clinical therapy need of a scalable, automated and fully closed process. The overall objective of our project is to develop and validate a closed, aseptic automated system for the manufacture of therapeutic stem cells.

In this project we will implement the: i) in vitro characterization of the cell product to determine identity, purity, potency; ii) in vitro investigation of the cell secretome for verification of trophic therapeutic factors and their therapeutic potential; iii)in vivo ectopic validation of cell product in a subcutaneous mouse model and diabetic mouse fracture repair mode, respectively.



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