3D coculture/organoid cultures of brain structures from neurodegenerative disease patient iPSCs
The lab of Dr. Verfaillie at the Stem Cell Institute Leuven is looking for a postdoctoral fellow with expertise in: The lab of Dr. Verfaillie at the Stem Cell Institute at KULeuven is recruiting an outstanding postdoctoral fellow highly versed in pluripotent stem cell biology techniques, including multicellular organoid cultures either in 2.5D and in 3D in suspension or in hydrogel based static or bioreactor cultures. The goal is to create lifelike small brain tissues, including the blood brain barrier or the cortex, that can be used as disease models in a dish, to study, Alzheimer's, Parkinson, frontotemporal dementia or ALS available from teams at KU Leuven and the Flemish Institute of Technology (VIB), using patient iPSC and their isogeneic counterparts. The technology should enable gaining superior insights in mature brain features such as defined connectivity and neuron-glia interactions, neurodegeneration phenotypes, and identification of drugable phenotypes.
KU Leuven, being the 6th European university in the 2017 Leiden ranking has a rich tradition of learning and research for almost six centuries.European surveys rank KU Leuven among the top European universities in terms of PhD degrees, international peer-reviewed publications and spin-off companies created and patent portfolio, supported by KULeuven Research & Development, one of the oldest and most renowned TTOs in Europe. The KU Leuven Stem Cell Institute, of which Dr. Verfaillie is the head, was founded in 2006 with as goals to further basic research in pluripotent and multipotent stem cell with emphasis on, basic research in de-differentiation and early differentiation of pluripotent stem cells, as well as stem cell biology in the fields of hematopoiesis,musculoskeletal, neurodegenerative and liver disorders. More information related to the Stem Cell Institute Leuven (SCIL) can be found at (http://www.kuleuven.be/scil/)
The successful candidate will work in close collaboration with students/postdocs in the team highly experienced in creating different neuronal, glial and endothelial cells from iPSC, as well as with CRISPR/Cas technology and CRISPR/Cas genome screening approaches. In addition, investigators from IMEC will be supporting this effort by providing sensors for continuous monitoring of differentiating cells in 2D, as well as innovative artificial substrates and microfluidics devices for reproducible co-culture of different cell types and organoids.
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